Enhancing the Accuracy of Platelet to Lymphocyte Ratio after Adjustment for Large Platelet Count : A Pilot Study in Breast Cancer Patients
Joint Authors
Salemis, Nikolaos S.
Seretis, Charalampos
Politou, Marianna
Gemenetzis, George
Athanasios, Panoutsopoulos
Emmanuel, Lagoudianakis E.
Source
International Journal of Surgical Oncology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The objective of our study is to investigate the potential effect of adjusting preoperative platelet to lymphocyte ratio, an emerging biomarker of survival in cancer patients, for the fraction of large platelets.
Methods.
A total of 79 patients with breast neoplasias, 44 with fibroadenomas, and 35 with invasive ductal carcinoma were included in the study.
Both conventional platelet to lymphocyte ratio (PLR) and the adjusted marker, large platelet to lymphocyte ratio (LPLR), were correlated with laboratory and histopathological parameters of the study sample.
Results.
LPLR elevation was significantly correlated with the presence of malignancy, advanced tumor stage, metastatic spread in the axillary nodes and HER2/neu overexpression, while PLR was only correlated with the number of infiltrated lymph nodes.
Conclusions.
This is the first study evaluating the effect of adjustment for large platelet count on improving PLR accuracy, when correlated with the basic independent markers of survival in a sample of breast cancer patients.
Further studies are needed in order to assess the possibility of applying our adjustment as standard in terms of predicting survival rates in cancer.
American Psychological Association (APA)
Seretis, Charalampos& Athanasios, Panoutsopoulos& Emmanuel, Lagoudianakis E.& Politou, Marianna& Gemenetzis, George& Salemis, Nikolaos S.. 2012. Enhancing the Accuracy of Platelet to Lymphocyte Ratio after Adjustment for Large Platelet Count : A Pilot Study in Breast Cancer Patients. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-488545
Modern Language Association (MLA)
Seretis, Charalampos…[et al.]. Enhancing the Accuracy of Platelet to Lymphocyte Ratio after Adjustment for Large Platelet Count : A Pilot Study in Breast Cancer Patients. International Journal of Surgical Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-488545
American Medical Association (AMA)
Seretis, Charalampos& Athanasios, Panoutsopoulos& Emmanuel, Lagoudianakis E.& Politou, Marianna& Gemenetzis, George& Salemis, Nikolaos S.. Enhancing the Accuracy of Platelet to Lymphocyte Ratio after Adjustment for Large Platelet Count : A Pilot Study in Breast Cancer Patients. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-488545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488545