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OxidativeNitrosative Stress and Protein Damages in Aqueous Humor of Hyperglycemic Rabbits : Effects of Two Oral Antidiabetics, Pioglitazone and Repaglinide
Joint Authors
Owczarek, Beata
Gumieniczek, Anna
Pawlikowska, Bernadeta
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The present study was undertaken to determine oxidative/nitrosative stress in aqueous humor of alloxan-induced hyperglycemic rabbits and to investigate the effects of two oral antidiabetic drugs, pioglitazone from peroxisome proliferator-activated receptor gamma (PPARγ) agonists and repaglinide from nonsulfonylurea KATP channel blockers.
Ascorbic acid (AA), glutathione (GSH), total antioxidant status (TAS), lipid peroxidation products (LPO), total nitrites (NO2), advanced oxidized protein products (AOPP), and protein carbonyl groups (PCG) were determined using respective colorimetric and ELISA methods.
In our hyperglycemic animals, AA decreased by 77%, GSH by 45%, and TAS by 66% as compared to control animals.
Simultaneously, LPO increased by 78%, PCG by 60%, AOPP by 84%, and NO2 by 70%.
In pioglitazone-treated animals, AA and TAS increased above control values while GSH and PCG were normalized.
In turn, LPO was reduced by 54%, AOPP by 84%, and NO2 by 24%, in relation to hyperglycemic rabbits.
With repaglinide, AA and TAS were normalized, GSH increased by 20%, while LPO decreased by 45%.
Our results show that pioglitazone and repaglinide differ significantly in their ability to ameliorate the parameters like NO2, PCG, and AOPP.
In this area, the multimodal action of pioglitazone as PPARγ agonist is probably essential.
American Psychological Association (APA)
Gumieniczek, Anna& Owczarek, Beata& Pawlikowska, Bernadeta. 2012. OxidativeNitrosative Stress and Protein Damages in Aqueous Humor of Hyperglycemic Rabbits : Effects of Two Oral Antidiabetics, Pioglitazone and Repaglinide. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-488551
Modern Language Association (MLA)
Gumieniczek, Anna…[et al.]. OxidativeNitrosative Stress and Protein Damages in Aqueous Humor of Hyperglycemic Rabbits : Effects of Two Oral Antidiabetics, Pioglitazone and Repaglinide. Experimental Diabetes Research No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-488551
American Medical Association (AMA)
Gumieniczek, Anna& Owczarek, Beata& Pawlikowska, Bernadeta. OxidativeNitrosative Stress and Protein Damages in Aqueous Humor of Hyperglycemic Rabbits : Effects of Two Oral Antidiabetics, Pioglitazone and Repaglinide. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-488551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488551