The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension : A Meta-Analysis
Author
Source
International Journal of Hypertension
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Single studies attempting to associate ANP gene T2238C (rs5065) polymorphism with hypertension have so far reported inconclusive results.
We therefore aimed to evaluate this association via a meta-analysis.
Data on 7 studies with a total of 4068 subjects were available and analyzed using the random-effects model with assessment of heterogeneity and publication bias.
Overall comparison of 2238C with 2238T yielded a 23% reduced, albeit nonsignificant, risk for hypertension (95% CI: 0.38–1.59; P=.485), while accompanying significant heterogeneity (I2=88.3%) and publication bias (P=.051).
Subgroup analysis by study design demonstrated opposite associations between population-based (OR=0.33; 95% CI: 0.13–0.80; P=.015) and hospital-based studies (OR=1.15; 95% CI: 0.79–1.68; P=.454).
Further meta-regression analysis exclusively indicated the significant influence of study design (P=.042) on heterogeneity.
Taken together, these findings support the notion that carriers of 2238C allele were at moderate decreased risk of developing hypertension, whereas study design was identified as a potentially significant source of between-study heterogeneity.
American Psychological Association (APA)
Niu, Wenquan. 2011. The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension : A Meta-Analysis. International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-488554
Modern Language Association (MLA)
Niu, Wenquan. The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension : A Meta-Analysis. International Journal of Hypertension No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-488554
American Medical Association (AMA)
Niu, Wenquan. The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension : A Meta-Analysis. International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-488554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488554