![](/images/graphics-bg.png)
An Overview of Brain-Derived Neurotrophic Factor and Implications for Excitotoxic Vulnerability in the Hippocampus
Joint Authors
Murray, Patrick S.
Holmes, Philip V.
Source
International Journal of Peptides
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The present paper examines the nature and function of brain-derived neurotrophic factor (BDNF) in the hippocampal formation and the consequences of changes in its expression.
The paper focuses on literature describing the role of BDNF in hippocampal development and neuroplasticity.
BDNF expression is highly sensitive to developmental and environmental factors, and increased BDNF signaling enhances neurogenesis, neurite sprouting, electrophysiological activity, and other processes reflective of a general enhancement of hippocampal function.
Such increases in activity may mediate beneficial effects such as enhanced learning and memory.
However, the increased activity also comes at a cost: BDNF plasticity renders the hippocampus more vulnerable to hyperexcitability and/or excitotoxic damage.
Exercise dramatically increases hippocampal BDNF levels and produces behavioral effects consistent with this phenomenon.
In analyzing the literature regarding exercise-induced regulation of BDNF, this paper provides a theoretical model for how the potentially deleterious consequences of BDNF plasticity may be modulated by other endogenous factors.
The peptide galanin may play such a role by regulating hippocampal excitability.
American Psychological Association (APA)
Murray, Patrick S.& Holmes, Philip V.. 2011. An Overview of Brain-Derived Neurotrophic Factor and Implications for Excitotoxic Vulnerability in the Hippocampus. International Journal of Peptides،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-488594
Modern Language Association (MLA)
Murray, Patrick S.& Holmes, Philip V.. An Overview of Brain-Derived Neurotrophic Factor and Implications for Excitotoxic Vulnerability in the Hippocampus. International Journal of Peptides No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-488594
American Medical Association (AMA)
Murray, Patrick S.& Holmes, Philip V.. An Overview of Brain-Derived Neurotrophic Factor and Implications for Excitotoxic Vulnerability in the Hippocampus. International Journal of Peptides. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-488594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488594