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The Effect of Recombinant Granulocyte Colony-Stimulating Factor on Oral and Periodontal Manifestations in a Patient with Cyclic Neutropenia : A Case Report
Joint Authors
Iorio Siciliano, Vincenzo
Andreuccetti, Gianmaria
Cafiero, Carlo
Daniele, Vincenzo
Matarasso, Sergio
Mignogna, Michele D.
Source
International Journal of Dentistry
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cyclic Neutropenia (CN) is characterized by recurrent infections, fever, oral ulcerations, and severe periodontitis as result of the reduced host defences.
The previous studies have established the effectiveness of recombinant granulocyte colony-stimulating factor (GCSF) to increase the number and the function of neutrophils in the peripheral blood in this disease.
In a 20-year-old Caucasian female with a diagnosis of cyclic neutropenia, oral clinical examination revealed multiple painful ulcerations of the oral mucosa, poor oral hygiene conditions, marginal gingivitis, and moderate periodontitis.
The patient received a treatment with G-CSF (Pegfilgrastim, 6 mg/month) in order to improve her immunological status.
Once a month nonsurgical periodontal treatment was carefully performed when absolute neutrophil count (ANC) was ≥500/μL.
The treatment with G-CSF resulted in a rapid increase of circulating neutrophils that, despite its short duration, leaded to a reduction in infection related events and the resolution of the multiple oral ulcerations.
The disappearance of oral pain allowed an efficacy nonsurgical treatment and a normal tooth brushing that determined a reduction of probing depth (PD≤4 mm) and an improvement of the oral hygiene conditions recorded at 6-month follow-up.
American Psychological Association (APA)
Matarasso, Sergio& Daniele, Vincenzo& Iorio Siciliano, Vincenzo& Mignogna, Michele D.& Andreuccetti, Gianmaria& Cafiero, Carlo. 2010. The Effect of Recombinant Granulocyte Colony-Stimulating Factor on Oral and Periodontal Manifestations in a Patient with Cyclic Neutropenia : A Case Report. International Journal of Dentistry،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-488606
Modern Language Association (MLA)
Matarasso, Sergio…[et al.]. The Effect of Recombinant Granulocyte Colony-Stimulating Factor on Oral and Periodontal Manifestations in a Patient with Cyclic Neutropenia : A Case Report. International Journal of Dentistry No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-488606
American Medical Association (AMA)
Matarasso, Sergio& Daniele, Vincenzo& Iorio Siciliano, Vincenzo& Mignogna, Michele D.& Andreuccetti, Gianmaria& Cafiero, Carlo. The Effect of Recombinant Granulocyte Colony-Stimulating Factor on Oral and Periodontal Manifestations in a Patient with Cyclic Neutropenia : A Case Report. International Journal of Dentistry. 2010. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-488606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488606