Ionotropic Glutamate Receptors and Voltage-Gated Ca2+ Channels in Long-Term Potentiation of Spinal Dorsal Horn Synapses and Pain Hypersensitivity
Joint Authors
Gerber, Gábor
Youn, Dong-ho
Sather, William A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-02
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Over the last twenty years of research on cellular mechanisms of pain hypersensitivity, long-term potentiation (LTP) of synaptic transmission in the spinal cord dorsal horn (DH) has emerged as an important contributor to pain pathology.
Mechanisms that underlie LTP of spinal DH neurons include changes in the numbers, activity, and properties of ionotropic glutamate receptors (AMPA and NMDA receptors) and of voltage-gated Ca2+ channels.
Here, we review the roles and mechanisms of these channels in the induction and expression of spinal DH LTP, and we present this within the framework of the anatomical organization and synaptic circuitry of the spinal DH.
Moreover, we compare synaptic plasticity in the spinal DH with classical LTP described for hippocampal synapses.
American Psychological Association (APA)
Youn, Dong-ho& Gerber, Gábor& Sather, William A.. 2013. Ionotropic Glutamate Receptors and Voltage-Gated Ca2+ Channels in Long-Term Potentiation of Spinal Dorsal Horn Synapses and Pain Hypersensitivity. Neural Plasticity،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-488609
Modern Language Association (MLA)
Youn, Dong-ho…[et al.]. Ionotropic Glutamate Receptors and Voltage-Gated Ca2+ Channels in Long-Term Potentiation of Spinal Dorsal Horn Synapses and Pain Hypersensitivity. Neural Plasticity No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-488609
American Medical Association (AMA)
Youn, Dong-ho& Gerber, Gábor& Sather, William A.. Ionotropic Glutamate Receptors and Voltage-Gated Ca2+ Channels in Long-Term Potentiation of Spinal Dorsal Horn Synapses and Pain Hypersensitivity. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-488609
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488609