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What Do Changes in Brain Perfusion Induced by Etomidate Suggest about Epilepsy in Human Patients?
Joint Authors
Domínguez-Gadea, Luis
Meilán, María Luisa
Sola, Rafael G.
Wix Ramos, Rybel
de Dios, Eva
Martínez-Chacón, José Luis
Pastor, Jesús
Herrera-Peco, Ivan
Source
Epilepsy Research and Treatment
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Epilepsy is one of the major neurological disorders, affecting roughly 1-2% of the world's population, of which approximately 20–25% of patients are drug resistant.
A variety of drugs have been used to activate and identify the epileptic area in patients during presurgical evaluation.
We studied the cerebral blood flow (CBF) by single photon-emission computed tomography (SPECT) and bioelectrical brain activity responses to etomidate in 11 patients.
Etomidate (0.1 mg/kg) was administered while patients were monitored by video-electroencephalography with foramen ovale electrodes (FOEs).
After etomidate administration, a brief period of high-frequency activity was observed, followed by a generalized, high-voltage delta pattern.
Increased regional CBF was observed bilaterally in thalamus, putamen, and posterior hippocampus.
Besides, the only interhemispheric difference was observed in the posterior hippocampus, where CBF decreased in the epileptic temporal lobe.
Activation by etomidate induces a specific and repetitive response in the bioelectrical activity.
In addition, CBF changes induced by etomidate may serve as a diagnostic tool in the near future.
American Psychological Association (APA)
Herrera-Peco, Ivan& Wix Ramos, Rybel& Domínguez-Gadea, Luis& Meilán, María Luisa& Martínez-Chacón, José Luis& de Dios, Eva…[et al.]. 2010. What Do Changes in Brain Perfusion Induced by Etomidate Suggest about Epilepsy in Human Patients?. Epilepsy Research and Treatment،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-488610
Modern Language Association (MLA)
Herrera-Peco, Ivan…[et al.]. What Do Changes in Brain Perfusion Induced by Etomidate Suggest about Epilepsy in Human Patients?. Epilepsy Research and Treatment No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-488610
American Medical Association (AMA)
Herrera-Peco, Ivan& Wix Ramos, Rybel& Domínguez-Gadea, Luis& Meilán, María Luisa& Martínez-Chacón, José Luis& de Dios, Eva…[et al.]. What Do Changes in Brain Perfusion Induced by Etomidate Suggest about Epilepsy in Human Patients?. Epilepsy Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-488610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488610