MicroRNA Implications across Neurodevelopment and Neuropathology
Joint Authors
Orlacchio, Antonio
Martino, Sabata
Orlacchio, Aldo
di Girolamo, Ilaria
Datti, Alessandro
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
MicroRNAs (miRNAs) have rapidly emerged as biologically important mediators of posttranscriptional and epigenetic regulation in both plants and animals.
miRNAs function through a variety of mechanisms including mRNA degradation and translational repression; additionally, miRNAs may guide gene expression by serving as transcription factors.
miRNAs are highly expressed in human brain.
Tissue and cell type-specific enrichments of certain miRNAs within the nervous system argue for a biological significance during neurodevelopmental stages.
On the other hand, a large number of studies have reported links between alterations of miRNA homeostasis and pathologic conditions such as cancer, heart diseases, and neurodegeneration.
Thus, profiles of distinct or aberrant miRNA signatures have most recently surged as one of the most fascinating interests in current biology.
Here, the most recent insights into the involvement of miRNAs in the biology of the nervous system and the occurrence of neuropathological disorders are reviewed and discussed.
American Psychological Association (APA)
Martino, Sabata& di Girolamo, Ilaria& Orlacchio, Antonio& Datti, Alessandro& Orlacchio, Aldo. 2009. MicroRNA Implications across Neurodevelopment and Neuropathology. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-488622
Modern Language Association (MLA)
Martino, Sabata…[et al.]. MicroRNA Implications across Neurodevelopment and Neuropathology. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-13.
https://search.emarefa.net/detail/BIM-488622
American Medical Association (AMA)
Martino, Sabata& di Girolamo, Ilaria& Orlacchio, Antonio& Datti, Alessandro& Orlacchio, Aldo. MicroRNA Implications across Neurodevelopment and Neuropathology. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-488622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488622