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Accurate Coregistration between Ultra-High-Resolution Micro-SPECT and Circular Cone-Beam Micro-CT Scanners
Joint Authors
van der Have, Frans
Ramakers, Ruud
Ji, Changguo
Gratama van Andel, Hugo
Beekman, Freek
Source
International Journal of Biomedical Imaging
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Introduction.
Spatially registering SPECT with CT makes it possible to anatomically localize SPECT tracers.
In this study, an accurate method for the coregistration of ultra-high-resolution SPECT volumes and multiple cone-beam CT volumes is developed and validated, which does not require markers during animal scanning.
Methods.
Transferable animal beds were developed with an accurate mounting interface.
Simple calibration phantoms make it possible to obtain both the spatial transformation matrix for stitching multiple CT scans of different parts of the animal and to register SPECT and CT.
The spatial transformation for image coregistration is calculated once using Horn's matching algorithm.
Animal images can then be coregistered without using markers.
Results.
For mouse-sized objects, average coregistration errors between SPECT and CT in X, Y, and Z directions are within 0.04 mm, 0.10 mm, and 0.19 mm, respectively.
For rat-sized objects, these numbers are 0.22 mm, 0.14 mm, and 0.28 mm.
Average 3D coregistration errors were within 0.24 mm and 0.42 mm for mouse and rat imaging, respectively.
Conclusion.
Extending the field-of-view of cone-beam CT by stitching is improved by prior registration of the CT volumes.
The accuracy of registration between SPECT and CT is typically better than the image resolution of current ultra-high-resolution SPECT.
American Psychological Association (APA)
Ji, Changguo& van der Have, Frans& Gratama van Andel, Hugo& Ramakers, Ruud& Beekman, Freek. 2010. Accurate Coregistration between Ultra-High-Resolution Micro-SPECT and Circular Cone-Beam Micro-CT Scanners. International Journal of Biomedical Imaging،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-488631
Modern Language Association (MLA)
Ji, Changguo…[et al.]. Accurate Coregistration between Ultra-High-Resolution Micro-SPECT and Circular Cone-Beam Micro-CT Scanners. International Journal of Biomedical Imaging No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-488631
American Medical Association (AMA)
Ji, Changguo& van der Have, Frans& Gratama van Andel, Hugo& Ramakers, Ruud& Beekman, Freek. Accurate Coregistration between Ultra-High-Resolution Micro-SPECT and Circular Cone-Beam Micro-CT Scanners. International Journal of Biomedical Imaging. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-488631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488631