![](/images/graphics-bg.png)
Role of Estrogen Receptor Signaling in Breast Cancer Metastasis
Joint Authors
Vadlamudi, Ratna K.
Saha Roy, Sudipa
Source
International Journal of Breast Cancer
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Metastatic breast cancer is a life-threatening stage of cancer and is the leading cause of death in advanced breast cancer patients.
Estrogen signaling and the estrogen receptor (ER) are implicated in breast cancer progression, and the majority of the human breast cancers start out as estrogen dependent.
Accumulating evidence suggests that ER signaling is complex, involving coregulatory proteins and extranuclear actions.
ER-coregualtory proteins are tightly regulated under normal conditions with miss expression primarily reported in cancer.
Deregulation of ER coregualtors or ER extranuclear signaling has potential to promote metastasis in ER-positive breast cancer cells.
This review summarizes the emerging role of ER signaling in promoting metastasis of breast cancer cells, discusses the molecular mechanisms by which ER signaling contributes to metastasis, and explores possible therapeutic targets to block ER-driven metastasis.
American Psychological Association (APA)
Saha Roy, Sudipa& Vadlamudi, Ratna K.. 2011. Role of Estrogen Receptor Signaling in Breast Cancer Metastasis. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-488646
Modern Language Association (MLA)
Saha Roy, Sudipa& Vadlamudi, Ratna K.. Role of Estrogen Receptor Signaling in Breast Cancer Metastasis. International Journal of Breast Cancer No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-488646
American Medical Association (AMA)
Saha Roy, Sudipa& Vadlamudi, Ratna K.. Role of Estrogen Receptor Signaling in Breast Cancer Metastasis. International Journal of Breast Cancer. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-488646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488646