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Cardiac Insulin Resistance and MicroRNA Modulators
Joint Authors
Gul, Rukhsana
Aroor, Annayya R.
Pulakat, Lakshmi
Sowers, James R.
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cardiac insulin resistance is a metabolic and functional disorder that is often associated with obesity and/or the cardiorenal metabolic syndrome (CRS), and this disorder may be accentuated by chronic alcohol consumption.
In conditions of over-nutrition, increased insulin (INS) and angiotensin II (Ang II) activate mammalian target for rapamycin (mTOR)/p70 S6 kinase (S6K1) signaling, whereas chronic alcohol consumption inhibits mTOR/S6K1 activation in cardiac tissue.
Although excessive activation of mTOR/S6K1 induces cardiac INS resistance via serine phosphorylation of INS receptor substrates (IRS-1/2), it also renders cardioprotection via increased Ang II receptor 2 (AT2R) upregulation and adaptive hypertrophy.
In the INS-resistant and hyperinsulinemic Zucker obese (ZO) rat, a rodent model for CRS, activation of mTOR/S6K1signaling in cardiac tissue is regulated by protective feed-back mechanisms involving mTOR↔AT2R signaling loop and profile changes of microRNA that target S6K1.
Such regulation may play a role in attenuating progressive heart failure.
Conversely, alcohol-mediated inhibition of mTOR/S6K1, down-regulation of INS receptor and growth-inhibitory mir-200 family, and upregulation of mir-212 that promotes fetal gene program may exacerbate CRS-related cardiomyopathy.
American Psychological Association (APA)
Pulakat, Lakshmi& Aroor, Annayya R.& Gul, Rukhsana& Sowers, James R.. 2011. Cardiac Insulin Resistance and MicroRNA Modulators. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-488671
Modern Language Association (MLA)
Pulakat, Lakshmi…[et al.]. Cardiac Insulin Resistance and MicroRNA Modulators. Experimental Diabetes Research No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-488671
American Medical Association (AMA)
Pulakat, Lakshmi& Aroor, Annayya R.& Gul, Rukhsana& Sowers, James R.. Cardiac Insulin Resistance and MicroRNA Modulators. Experimental Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-488671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488671