Epigenetic Effects and Molecular Mechanisms of Tumorigenesis Induced by Cigarette Smoke : An Overview
Joint Authors
Chang, Louis W.
Lin, Pinpin
Chen, Rong-Jane
Wang, Ying-Jan
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cigarette smoking is one of the major causes of carcinogenesis.
Direct genotoxicity induced by cigarette smoke leads to initiation of carcinogenesis.
Nongenotoxic (epigenetic) effects of cigarette smoke also act as modulators altering cellular functions.
These two effects underlie the mechanisms of tumor promotion and progression.
While there is no lack of general reviews on the genotoxic and carcinogenic potentials of cigarette smoke in lung carcinogenesis, updated review on the epigenetic effects and molecular mechanisms of cigarette smoke and carcinogenesis, not limited to lung, is lacking.
We are presenting a comprehensive review of recent investigations on cigarette smoke, with special attentions to nicotine, NNK, and PAHs.
The current understanding on their molecular mechanisms include (1) receptors, (2) cell cycle regulators, (3) signaling pathways, (4) apoptosis mediators, (5) angiogenic factors, and (6) invasive and metastasis mediators.
This review highlighted the complexity biological responses to cigarette smoke components and their involvements in tumorigenesis.
American Psychological Association (APA)
Chen, Rong-Jane& Chang, Louis W.& Lin, Pinpin& Wang, Ying-Jan. 2011. Epigenetic Effects and Molecular Mechanisms of Tumorigenesis Induced by Cigarette Smoke : An Overview. Journal of Oncology،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-488674
Modern Language Association (MLA)
Chen, Rong-Jane…[et al.]. Epigenetic Effects and Molecular Mechanisms of Tumorigenesis Induced by Cigarette Smoke : An Overview. Journal of Oncology No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-488674
American Medical Association (AMA)
Chen, Rong-Jane& Chang, Louis W.& Lin, Pinpin& Wang, Ying-Jan. Epigenetic Effects and Molecular Mechanisms of Tumorigenesis Induced by Cigarette Smoke : An Overview. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-488674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488674