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Signal Protein-Derived Peptides as Functional Probes and Regulators of Intracellular Signaling
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-23
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
The functionally important regions of signal proteins participating in their specific interaction and responsible for transduction of hormonal signal into cell are rather short in length, having, as a rule, 8 to 20 amino acid residues.
Synthetic peptides corresponding to these regions are able to mimic the activated form of full-size signal protein and to trigger signaling cascades in the absence of hormonal stimulus.
They modulate protein-protein interaction and influence the activity of signal proteins followed by changes in their regulatory and catalytic sites.
The present review is devoted to the achievements and perspectives of the study of signal protein-derived peptides and to their application as selective and effective regulators of hormonal signaling systems in vitro and in vivo.
Attention is focused on the structure, biological activity, and molecular mechanisms of action of peptides, derivatives of the receptors, G protein α subunits, and the enzymes generating second messengers.
American Psychological Association (APA)
Shpakov, Alexander O.. 2011. Signal Protein-Derived Peptides as Functional Probes and Regulators of Intracellular Signaling. Journal of Amino Acids،Vol. 2011, no. 2011, pp.1-25.
https://search.emarefa.net/detail/BIM-488692
Modern Language Association (MLA)
Shpakov, Alexander O.. Signal Protein-Derived Peptides as Functional Probes and Regulators of Intracellular Signaling. Journal of Amino Acids No. 2011 (2011), pp.1-25.
https://search.emarefa.net/detail/BIM-488692
American Medical Association (AMA)
Shpakov, Alexander O.. Signal Protein-Derived Peptides as Functional Probes and Regulators of Intracellular Signaling. Journal of Amino Acids. 2011. Vol. 2011, no. 2011, pp.1-25.
https://search.emarefa.net/detail/BIM-488692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488692