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Programmed Death Ligand 2 in Cancer-Induced Immune Suppression
Joint Authors
Robinson, Bruce W. S.
Rozali, Esdy N.
Lake, Richard A.
Lesterhuis, W. Joost
Hato, Stanleyson V.
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Inhibitory molecules of the B7/CD28 family play a key role in the induction of immune tolerance in the tumor microenvironment.
The programmed death-1 receptor (PD-1), with its ligands PD-L1 and PD-L2, constitutes an important member of these inhibitory pathways.
The relevance of the PD-1/PD-L1 pathway in cancer has been extensively studied and therapeutic approaches targeting PD-1 and PD-L1 have been developed and are undergoing human clinical testing.
However, PD-L2 has not received as much attention and its role in modulating tumor immunity is less clear.
Here, we review the literature on the immunobiology of PD-L2, particularly on its possible roles in cancer-induced immune suppression and we discuss the results of recent studies targeting PD-L2 in cancer.
American Psychological Association (APA)
Rozali, Esdy N.& Hato, Stanleyson V.& Robinson, Bruce W. S.& Lake, Richard A.& Lesterhuis, W. Joost. 2012. Programmed Death Ligand 2 in Cancer-Induced Immune Suppression. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-488714
Modern Language Association (MLA)
Rozali, Esdy N.…[et al.]. Programmed Death Ligand 2 in Cancer-Induced Immune Suppression. Clinical and Developmental Immunology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-488714
American Medical Association (AMA)
Rozali, Esdy N.& Hato, Stanleyson V.& Robinson, Bruce W. S.& Lake, Richard A.& Lesterhuis, W. Joost. Programmed Death Ligand 2 in Cancer-Induced Immune Suppression. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-488714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488714