Peroxisome Proliferator-Activated Receptors in Regulation of Cytochromes P450 : New Way to Overcome Multidrug Resistance?
Joint Authors
Cizkova, Katerina
Lichnovska, Radka
Ehrmann, Jiri
Erdosova, Bela
Konieczna, Anna
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Embryonic and tumour cells are able to protect themselves against various harmful compounds.
In human pathology, this phenomenon exists in the form of multidrug resistance (MDR) that significantly deteriorates success of anticancer treatment.
Cytochromes P450 (CYPs) play one of the key roles in the xenobiotic metabolism.
CYP expression could contribute to resistance of cancer cells to chemotherapy.
CYP epoxygenases (CYP2C and CYP2J) metabolize about 20% of clinically important drugs.
Besides of drug metabolism, CYP epoxygenases and their metabolites play important role in embryos, normal body function, and tumors.
They participate in angiogenesis, mitogenesis, and cell signaling.
It was found that CYP epoxygenases are affected by peroxisome proliferator-activated receptor α (PPARα).
Based on the results of current studies, we assume that PPARs ligands may regulate CYP2C and CYP2J and in some extent they may contribute to overcoming of MDR in patients with different types of tumours.
American Psychological Association (APA)
Cizkova, Katerina& Konieczna, Anna& Erdosova, Bela& Lichnovska, Radka& Ehrmann, Jiri. 2012. Peroxisome Proliferator-Activated Receptors in Regulation of Cytochromes P450 : New Way to Overcome Multidrug Resistance?. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-488725
Modern Language Association (MLA)
Cizkova, Katerina…[et al.]. Peroxisome Proliferator-Activated Receptors in Regulation of Cytochromes P450 : New Way to Overcome Multidrug Resistance?. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-488725
American Medical Association (AMA)
Cizkova, Katerina& Konieczna, Anna& Erdosova, Bela& Lichnovska, Radka& Ehrmann, Jiri. Peroxisome Proliferator-Activated Receptors in Regulation of Cytochromes P450 : New Way to Overcome Multidrug Resistance?. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-488725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488725