Pentraxin 3 : A Novel Biomarker for Inflammatory Cardiovascular Disease
Joint Authors
Kodama, Tatsuhiko
Inoue, Kenji
Daida, Hiroyuki
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Numerous studies have recently examined the role of pentraxin 3 (PTX3) in clinical situations.
The pentraxin family includes C-reactive protein (CRP); however, unlike CRP, PTX3 is expressed predominantly in atherosclerotic lesions that involve macrophages, neutrophils, dendritic cells, or smooth muscle cells.
Interestingly, PTX3 gene expression in human endothelial cells is suppressed to a greater extent by pitavastatin than the expression of 6,000 other human genes that have been examined, suggesting that PTX3 may be a novel biomarker for inflammatory cardiovascular disease.
The expression and involvement of PTX3 in cardiovascular diseases are discussed in this paper, along with the characteristics of PTX3 that make it a suitable biomarker; namely, that the physiological concentration is known and it is independent of other risk factors.
The results discussed in this paper suggest that further investigations into the potential novel use of PTX3 as a biomarker for inflammatory cardiovascular disease should be undertaken.
American Psychological Association (APA)
Inoue, Kenji& Kodama, Tatsuhiko& Daida, Hiroyuki. 2012. Pentraxin 3 : A Novel Biomarker for Inflammatory Cardiovascular Disease. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-488760
Modern Language Association (MLA)
Inoue, Kenji…[et al.]. Pentraxin 3 : A Novel Biomarker for Inflammatory Cardiovascular Disease. International Journal of Vascular Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-488760
American Medical Association (AMA)
Inoue, Kenji& Kodama, Tatsuhiko& Daida, Hiroyuki. Pentraxin 3 : A Novel Biomarker for Inflammatory Cardiovascular Disease. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-488760
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488760