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The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth
Joint Authors
Olgun, Nicole S.
Reznik, Sandra E.
Source
Obstetrics and Gynecology International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Preterm birth (PTB) is clinically defined as any delivery which occurs before the completion of 37 weeks of gestation, and is currently the most important problem in obstetrics.
In the United States, PTB accounts for 12-13% of all live births, and, with the exception of fetuses suffering from anomalies, is the primary cause of perinatal mortality.
While the risk factors for PTB are numerous, the single most common cause is intrauterine infection.
As there is currently no FDA-approved therapy for infection-associated PTB, understanding the pathogenesis of preterm labor (PTL) and delivery should be given high priority.
The matrix metalloproteinases (MMPs) are a family of enzymes that have been implicated in normal parturition as well as infection-triggered rupture of membranes and preterm birth.
Several lines of evidence also suggest a role for endothelin-1 (ET-1) in infection-associated preterm delivery.
This paper focuses on the evidence that the MMPs and ET-1 act in the same molecular pathway in preterm birth.
American Psychological Association (APA)
Olgun, Nicole S.& Reznik, Sandra E.. 2010. The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth. Obstetrics and Gynecology International،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-488761
Modern Language Association (MLA)
Olgun, Nicole S.& Reznik, Sandra E.. The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth. Obstetrics and Gynecology International No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-488761
American Medical Association (AMA)
Olgun, Nicole S.& Reznik, Sandra E.. The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth. Obstetrics and Gynecology International. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-488761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488761