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Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies
Joint Authors
Sánchez-Sevilla, Lourdes
García-García, Norberto
Hernández-Muñoz, Rolando
Olguín-Martínez, Marisela
Aguilar-Delfín, Irma
Díaz-Muñoz, Mauricio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
There is an important set of cirrhotic and diabetic patients that present both diseases.
However, information about metabolic and cellular blood markers that are altered, in conjunction or distinctively, in the 3 pathological conditions is scarce.
The aim of this project was to evaluate several indicators of prooxidant reactions and the membrane composition of blood samples (serum and red blood cells (RBCs)) from patients clinically classified as diabetic (n=60), cirrhotic (n=70), and diabetic with liver cirrhosis (n=25) as compared to samples from a similar population of healthy individuals (n=60).
The results showed that levels of TBARS, nitrites, cysteine, and conjugated dienes in the RBC of cirrhotic patients were significantly increased.
However, the coincidence of diabetes and cirrhosis partially reduced the alterations promoted by the cirrhotic condition.
The amount of total phospholipids and cholesterol was greatly enhanced in the patients with both pathologies (between 60 and 200% according to the type of phospholipid) but not in the patients with only one disease.
Overall, the data indicate that the cooccurrence of diabetes and cirrhosis elicits a physiopathological equilibrium that is different from the alterations typical of each individual malady.
American Psychological Association (APA)
Hernández-Muñoz, Rolando& Olguín-Martínez, Marisela& Aguilar-Delfín, Irma& Sánchez-Sevilla, Lourdes& García-García, Norberto& Díaz-Muñoz, Mauricio. 2013. Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-488794
Modern Language Association (MLA)
Hernández-Muñoz, Rolando…[et al.]. Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-488794
American Medical Association (AMA)
Hernández-Muñoz, Rolando& Olguín-Martínez, Marisela& Aguilar-Delfín, Irma& Sánchez-Sevilla, Lourdes& García-García, Norberto& Díaz-Muñoz, Mauricio. Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-488794
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488794