Metastatic Melanomas Express Inhibitory Low Affinity Fc Gamma Receptor and Escape Humoral Immunity
Joint Authors
Cohen-Solal, Joel F. G.
Sautès-Fridman, Catherine
Fridman, Wolf Herman
Fournier, Emilie M.
Loncar, Shannon M.
Cassard, Lydie
Source
Dermatology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Our research, inspired by the pioneering works of Isaac Witz in the 1980s, established that 40% of human metastatic melanomas express ectopically inhibitory Fc gamma receptors (FcγRIIB), while they are detected on less than 5% of primary cutaneous melanoma and not on melanocytes.
We demonstrated that these tumoral FcγRIIB act as decoy receptors that bind the Fc portion of antimelanoma IgG, which may prevent Fc recognition by the effector cells of the immune system and allow the metastatic melanoma to escape the humoral/natural immune response.
The FcγRIIB is able to inhibit the ADCC (antibody dependent cell cytotoxicity) in vitro.
Interestingly, the percentage of melanoma expressing the FcγRIIB is high (70%) in organs like the liver, which is rich in patrolling NK (natural killer) cells that exercise their antitumoral activity by ADCC.
We found that this tumoral FcγRIIB is fully functional and that its inhibitory potential can be triggered depending on the specificity of the anti-tumor antibody with which it interacts.
Together these observations elucidate how metastatic melanomas interact with and potentially evade humoral immunity and provide direction for the improvement of anti-melanoma monoclonal antibody therapy.
American Psychological Association (APA)
Cohen-Solal, Joel F. G.& Cassard, Lydie& Fournier, Emilie M.& Loncar, Shannon M.& Fridman, Wolf Herman& Sautès-Fridman, Catherine. 2010. Metastatic Melanomas Express Inhibitory Low Affinity Fc Gamma Receptor and Escape Humoral Immunity. Dermatology Research and Practice،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-488796
Modern Language Association (MLA)
Cohen-Solal, Joel F. G.…[et al.]. Metastatic Melanomas Express Inhibitory Low Affinity Fc Gamma Receptor and Escape Humoral Immunity. Dermatology Research and Practice No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-488796
American Medical Association (AMA)
Cohen-Solal, Joel F. G.& Cassard, Lydie& Fournier, Emilie M.& Loncar, Shannon M.& Fridman, Wolf Herman& Sautès-Fridman, Catherine. Metastatic Melanomas Express Inhibitory Low Affinity Fc Gamma Receptor and Escape Humoral Immunity. Dermatology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-488796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488796