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Limitations of Animal Models of Parkinson's Disease
Joint Authors
Blume, S. R.
Runkle, N. K.
Potashkin, J. A.
Source
International Journal of Pediatrics
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Most cases of Parkinson's disease (PD) are sporadic.
When choosing an animal model for idiopathic PD, one must consider the extent of similarity or divergence between the physiology, anatomy, behavior, and regulation of gene expression between humans and the animal.
Rodents and nonhuman primates are used most frequently in PD research because when a Parkinsonian state is induced, they mimic many aspects of idiopathic PD.
These models have been useful in our understanding of the etiology of the disease and provide a means for testing new treatments.
However, the current animal models often fall short in replicating the true pathophysiology occurring in idiopathic PD, and thus results from animal models often do not translate to the clinic.
In this paper we will explain the limitations of animal models of PD and why their use is inappropriate for the study of some aspects of PD.
American Psychological Association (APA)
Potashkin, J. A.& Blume, S. R.& Runkle, N. K.. 2010. Limitations of Animal Models of Parkinson's Disease. International Journal of Pediatrics،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-488862
Modern Language Association (MLA)
Potashkin, J. A.…[et al.]. Limitations of Animal Models of Parkinson's Disease. International Journal of Pediatrics No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-488862
American Medical Association (AMA)
Potashkin, J. A.& Blume, S. R.& Runkle, N. K.. Limitations of Animal Models of Parkinson's Disease. International Journal of Pediatrics. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-488862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488862