Day 100 Peripheral Blood Absolute LymphocyteMonocyte Ratio and Survival in Classical Hodgkin's Lymphoma Postautologous Peripheral Blood Hematopoietic Stem Cell Transplantation
Joint Authors
Inwards, David J.
Ansell, Stephen M.
Johnston, Patrick B.
Micallef, Ivana N.
Porrata, Luis F.
Markovic, Svetomir N.
Hogan, William J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Day 100 prognostic factors of postautologous peripheral blood hematopoietic stem cell transplantation (APBHSCT) to predict clinical outcome in classical Hodgkin lymphoma (cHL) patients have not been evaluated.
Thus, we studied if the day 100 peripheral blood absolute lymphocyte/monocyte ratio (Day 100 ALC/AMC) affects clinical outcomes by landmark analysis from day 100 post-APBHSCT.
Only cHL patients achieving a complete remission at day 100 post-APBHSCT were studied.
From 2000 to 2010, 131 cHL consecutive patients qualified for the study.
The median followup from day 100 was 4.1 years (range: 0.2–12.3 years).
Patients with a Day 100 ALC/AMC ≥ 1.3 experienced superior overall survival (OS) and progression-free survival (PFS) compared with Day 100 ALC/AMC < 1.3 (from day 100: OS, median not reached versus 2.8 years; 5 years OS rates of 93% (95% CI, 83%–97%) versus 35% (95% CI, 19%–51%), resp., P<0.0001; from day 100: PFS, median not reached versus 1.2 years; 5 years PFS rates of 79% (95% CI, 69%–86%) versus 27% (95% CI, 14%–45%), resp., P<0.0001).
Day ALC/AMC ratio was an independent predictor for OS and PFS.
Thus, Day 100 ALC/AMC ratio is a simple biomarker that can help to assess clinical outcomes from day 100 post-APBHSCT in cHL patients.
American Psychological Association (APA)
Porrata, Luis F.& Inwards, David J.& Ansell, Stephen M.& Micallef, Ivana N.& Johnston, Patrick B.& Hogan, William J.…[et al.]. 2013. Day 100 Peripheral Blood Absolute LymphocyteMonocyte Ratio and Survival in Classical Hodgkin's Lymphoma Postautologous Peripheral Blood Hematopoietic Stem Cell Transplantation. Bone Marrow Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-488890
Modern Language Association (MLA)
Porrata, Luis F.…[et al.]. Day 100 Peripheral Blood Absolute LymphocyteMonocyte Ratio and Survival in Classical Hodgkin's Lymphoma Postautologous Peripheral Blood Hematopoietic Stem Cell Transplantation. Bone Marrow Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-488890
American Medical Association (AMA)
Porrata, Luis F.& Inwards, David J.& Ansell, Stephen M.& Micallef, Ivana N.& Johnston, Patrick B.& Hogan, William J.…[et al.]. Day 100 Peripheral Blood Absolute LymphocyteMonocyte Ratio and Survival in Classical Hodgkin's Lymphoma Postautologous Peripheral Blood Hematopoietic Stem Cell Transplantation. Bone Marrow Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-488890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488890