![](/images/graphics-bg.png)
Age-Related Alterations in Endothelial Function of Femoral Artery in Young SHR and WKY Rats
Joint Authors
Balis, Peter
Bernatova, Iveta
Ilovska, Veronika
Slezak, Peter
Puzserova, Angelika
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The present study was designed to evaluate the effects of vascular aging in juvenescence on endothelial function in femoral arteries and to assess differences between normotensive and hypertensive rats.
The aim of the study was to determine if age affected nitric oxide- (NO-) mediated relaxations in normotensive and hypertensive rats.
Juvenile (7-week-old) and young adult (22-week-old) male Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) were used in this study.
Femoral artery (FA) reactivity was determined by wire myograph and NO synthase activity by conversion of [3H]-L-arginine.
During juvenescence systolic blood pressure (tail-cuff) increased significantly only in SHR, while NO synthesis decreased significantly in both strains.
Endothelium-dependent relaxations to acetylcholine were reduced in the FA of SHR compared to age-matched WKY at both ages, yet these parameters were unchanged in adult rats compared with juvenile animals.
The NO-dependent component of vasorelaxation was markedly reduced, whereas the NO-independent component was increased in adult compared to juvenile rats in both strains.
The endothelial dysfunction in SHR at both ages was associated with reduction of NO-independent mechanisms.
In conclusion, aging in early periods of life was associated with reduction of vascular NO production and bioavailability in both strains investigated.
This reduction was however fully compensated by accentuation of NO-independent mechanisms.
American Psychological Association (APA)
Puzserova, Angelika& Ilovska, Veronika& Balis, Peter& Slezak, Peter& Bernatova, Iveta. 2014. Age-Related Alterations in Endothelial Function of Femoral Artery in Young SHR and WKY Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-488901
Modern Language Association (MLA)
Puzserova, Angelika…[et al.]. Age-Related Alterations in Endothelial Function of Femoral Artery in Young SHR and WKY Rats. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-488901
American Medical Association (AMA)
Puzserova, Angelika& Ilovska, Veronika& Balis, Peter& Slezak, Peter& Bernatova, Iveta. Age-Related Alterations in Endothelial Function of Femoral Artery in Young SHR and WKY Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-488901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488901