Development of an Inflammation-Associated Colorectal Cancer Model and Its Application for Research on Carcinogenesis and Chemoprevention
Author
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Chronic inflammation is a well-recognized risk factor for development of human cancer in several tissues, including large bowel.
Inflammatory bowel disease, including ulcerative colitis and Crohn’s disease, is a longstanding inflammatory disease of intestine with increased risk for colorectal cancer development.
Several molecular events involved in chronic inflammatory process may contribute to multistep carcinogenesis of human colorectal cancer in the inflamed colon.
They include overproduction of reactive oxygen and nitrogen species, overproduction and upregulation of productions and enzymes of arachidonic acid biosynthesis pathway and cytokines, and intestinal immune system dysfunction.
In this paper, I will describe several methods to induce colorectal neoplasm in the inflamed colon.
First, I will introduce a protocol of a novel inflammation-associated colon carcinogenesis in mice.
In addition, powerful tumor-promotion/progression activity of dextran sodium sulfate in the large bowel of ApcMin/+ mice will be described.
Finally, chemoprevention of inflammation-associated colon carcinogenesis will be mentioned.
American Psychological Association (APA)
Tanaka, Takuji. 2012. Development of an Inflammation-Associated Colorectal Cancer Model and Its Application for Research on Carcinogenesis and Chemoprevention. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-488937
Modern Language Association (MLA)
Tanaka, Takuji. Development of an Inflammation-Associated Colorectal Cancer Model and Its Application for Research on Carcinogenesis and Chemoprevention. International Journal of Inflammation No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-488937
American Medical Association (AMA)
Tanaka, Takuji. Development of an Inflammation-Associated Colorectal Cancer Model and Its Application for Research on Carcinogenesis and Chemoprevention. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-488937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488937