Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease : Effects on Voice Intensity
Joint Authors
Lundgren, Sofie
Zafar, Hamayun
Nordh, Erik
Olofsson, Katarina
van Doorn, Jan
Saeys, Thomas
Karlsson, Fredrik
Linder, Jan
Blomstedt, Patric
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Deep brain stimulation of the subthalamic nucleus (STN-DBS) in patients with Parkinson's disease (PD) affects speech inconsistently.
Recently, stimulation of the caudal zona incerta (cZi-DBS) has shown superior motor outcomes for PD patients, but effects on speech have not been systematically investigated.
The aim of this study was to compare the effects of cZi-DBS and STN-DBS on voice intensity in PD patients.
Mean intensity during reading and intensity decay during rapid syllable repetition were measured for STN-DBS and cZi-DBS patients (eight patients per group), before- and 12 months after-surgery on- and off-stimulation.
For mean intensity, there were small significant differences on- versus off-stimulation in each group: 74.2 (2.0) dB contra 72.1 (2.2) dB (P=.002) for STN-DBS, and 71.6 (4.1) dB contra 72.8 (3.4) dB (P=.03) for cZi-DBS, with significant interaction (P<.001).
Intensity decay showed no significant changes.
The subtle differences found for mean intensity suggest that STN-DBS and cZi-DBS may influence voice intensity differently.
American Psychological Association (APA)
Lundgren, Sofie& Saeys, Thomas& Karlsson, Fredrik& Olofsson, Katarina& Blomstedt, Patric& Linder, Jan…[et al.]. 2011. Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease : Effects on Voice Intensity. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-488951
Modern Language Association (MLA)
Lundgren, Sofie…[et al.]. Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease : Effects on Voice Intensity. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-488951
American Medical Association (AMA)
Lundgren, Sofie& Saeys, Thomas& Karlsson, Fredrik& Olofsson, Katarina& Blomstedt, Patric& Linder, Jan…[et al.]. Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease : Effects on Voice Intensity. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-488951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488951