Acetonic and Methanolic Extracts of Heterotheca inuloides, and Quercetin, Decrease CCl4-Oxidative Stress in Several Rat Tissues
Joint Authors
Cárdenas-Rodríguez, Noemí
Montesinos-Correa, Hortencia
Espinosa-Aguirre, Jesús Javier
Huerta-Gertrudis, Bernardino
García-Cruz, Mercedes Edna
Pedraza-Chaverri, José
Coballase-Urrutia, Elvia
Camacho-Carranza, Rafael
Sánchez-González, Dolores Javier
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The present study was designed to test the hypothesis that the acetonic and methanolic extracts of H.
inuloides prevent carbon tetrachloride-(CCl4) induced oxidative stress in vital tissues.
Pretreatment with both H.
inuloides extracts or quercetin attenuated the increase in serum activity of alkaline phosphatase (ALP), total bilirubin (BB), creatinine (CRE), and creatine kinase (CK), and impeded the decrease of γ-globulin (γ-GLOB) and albumin (ALB) observed in CCl4-induced tissue injury.
The protective effect was confirmed by histological analysis with hematoxylin-eosin and periodic acid/Schiff's reagent.
Level of lipid peroxidation was higher in the organs of rats exposed to CCl4 than in those of the animals treated with Heterohteca extracts or quercetin, and these showed levels similar to the untreated group.
Pretreatment of animals with either of the extracts or quercetin also prevented the increase of 4-hydroxynonenal and 3-nitrotyrosine.
Pretreatment with the plant extracts or quercetin attenuated CCl4 toxic effects on the activity of several antioxidant enzymes.
The present results strongly suggest that the chemopreventive effect of the extracts used and quercetin, against CCl4 toxicity, is associated with their antioxidant properties and corroborated previous results obtained in liver tissue.
American Psychological Association (APA)
Coballase-Urrutia, Elvia& Pedraza-Chaverri, José& Cárdenas-Rodríguez, Noemí& Huerta-Gertrudis, Bernardino& García-Cruz, Mercedes Edna& Montesinos-Correa, Hortencia…[et al.]. 2013. Acetonic and Methanolic Extracts of Heterotheca inuloides, and Quercetin, Decrease CCl4-Oxidative Stress in Several Rat Tissues. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-488975
Modern Language Association (MLA)
Coballase-Urrutia, Elvia…[et al.]. Acetonic and Methanolic Extracts of Heterotheca inuloides, and Quercetin, Decrease CCl4-Oxidative Stress in Several Rat Tissues. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-488975
American Medical Association (AMA)
Coballase-Urrutia, Elvia& Pedraza-Chaverri, José& Cárdenas-Rodríguez, Noemí& Huerta-Gertrudis, Bernardino& García-Cruz, Mercedes Edna& Montesinos-Correa, Hortencia…[et al.]. Acetonic and Methanolic Extracts of Heterotheca inuloides, and Quercetin, Decrease CCl4-Oxidative Stress in Several Rat Tissues. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-488975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488975