![](/images/graphics-bg.png)
Role of Angiopoietin-2 in Regulating Growth and Vascularity of Astrocytomas
Joint Authors
Zadeh, Gelareh
Baoping, Qian
Shannon, Patrick
Guha, Abhijit
Koushan, Keyvan
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Angiopoietins and Tie2 are angiogenic-specific ligand and receptor complex that have been shown to play a critical role in tumor angiogenesis.
Angiopoietin-2 (Ang2) is one of four ligands for receptor Tie2 and it is the naturally occurring antagonist to Tie2, inhibiting the action of Angiopoietin-1 (Ang1).
Over the last decade, significant research has focused on elucidating the role of Ang2 in cancer biology and its exact role in tumor angiogenesis remains elusive.
In this study we have focused on establishing the role of Ang2 in angiogenesis of malignant astrocytomas.
We have demonstrated that Ang2 significantly enhances the vascular growth of malignant astrocytomas and constant upregulation of Ang2 throughout all phases of tumor growth generates abnormal vascular structures that are not typically seen in human astrocytomas, suggesting that Ang2 plays a tumor stage-dependent role and is not a consistently elevated throughout all growth stages of malignant astroctyomas.
American Psychological Association (APA)
Zadeh, Gelareh& Koushan, Keyvan& Baoping, Qian& Shannon, Patrick& Guha, Abhijit. 2010. Role of Angiopoietin-2 in Regulating Growth and Vascularity of Astrocytomas. Journal of Oncology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-488980
Modern Language Association (MLA)
Zadeh, Gelareh…[et al.]. Role of Angiopoietin-2 in Regulating Growth and Vascularity of Astrocytomas. Journal of Oncology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-488980
American Medical Association (AMA)
Zadeh, Gelareh& Koushan, Keyvan& Baoping, Qian& Shannon, Patrick& Guha, Abhijit. Role of Angiopoietin-2 in Regulating Growth and Vascularity of Astrocytomas. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-488980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488980