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Eryptotic Phenotype in Chronic Myeloid Leukemia : Contribution of Neutrophilic Cathepsin G
Joint Authors
Govekar, Rukmini B.
Thomas, Renjan
PV, Sheena
Advani, Suresh H.
Kawle, Poonam D.
Zingde, Surekha M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In pathological conditions with concurrent neutrophilia, modifications of erythrocyte membrane proteins are reported.
In chronic myeloid leukemia (CML), a myeloproliferative disease wherein neutrophilia is accompanied by enhanced erythrophagocytosis, we report for the first time excessive cleavage of erythrocyte band 3.
Distinct fragments of band 3 serve as senescent cell antigens leading to erythrophagocytosis.
Using immunoproteomics, we report the identification of immunogenic 43 kDa fragment of band 3 in 68% of CML samples compared to their detection in only 38% of healthy individuals.
Thus, excessive fragmentation of band 3 in CML, detected in our study, corroborated with the eryptotic phenotype.
We demonstrate the role of neutrophilic cathepsin G, detected as an immunogen on erythrocyte membrane, in band 3 cleavage.
Cathepsin G from serum adsorbs to the erythrocyte membrane to mediate cleavage of band 3 and therefore contribute to the eryptotic phenotype in CML.
American Psychological Association (APA)
Govekar, Rukmini B.& Kawle, Poonam D.& Thomas, Renjan& Advani, Suresh H.& PV, Sheena& Zingde, Surekha M.. 2012. Eryptotic Phenotype in Chronic Myeloid Leukemia : Contribution of Neutrophilic Cathepsin G. Anemia،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-488994
Modern Language Association (MLA)
Govekar, Rukmini B.…[et al.]. Eryptotic Phenotype in Chronic Myeloid Leukemia : Contribution of Neutrophilic Cathepsin G. Anemia No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-488994
American Medical Association (AMA)
Govekar, Rukmini B.& Kawle, Poonam D.& Thomas, Renjan& Advani, Suresh H.& PV, Sheena& Zingde, Surekha M.. Eryptotic Phenotype in Chronic Myeloid Leukemia : Contribution of Neutrophilic Cathepsin G. Anemia. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-488994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488994