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Hypoxic-Ischemic Neonatal Encephalopathy : Animal Experiments for Neuroprotective Therapies
Joint Authors
Sameshima, Hiroshi
Ikenoue, Tsuyomu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hypoxic-ischemic neonatal encephalopathy and ensuing brain damage is still an important problem in modern perinatal medicine.
In this paper, we would like to share some of the results of our recent studies on neuroprotective therapies in animal experiments, as well as some literature reviews.
From the basic animal studies, we have now obtained some possible candidates for therapeutic measures against hypoxic-ischemic neonatal encephalopathy.
For example, they are hypothermia, rehabilitation, free radical scavenger, neurotrophic factors and growth factors, steroid, calcium channel blocker, vagal stimulation, some anti apoptotic agents, pre- and post conditioning, antioxidants, cell therapy with stem cells, modulators of K(+)-ATP channels, and so on.
Whether combination of these therapies may be more beneficial than any single therapy needs to be clarified.
Hypoxia-ischemia is a complicated condition, in which the cause, severity, and time-course are different in each case.
Likewise, each fetus has its own inherent potentials such as adaptation, preconditioning-tolerance, and intolerance.
Therefore, further extensive studies are required to establish an individualized strategy for neuroprotection against perinatal hypoxic-ischemic insult.
American Psychological Association (APA)
Sameshima, Hiroshi& Ikenoue, Tsuyomu. 2013. Hypoxic-Ischemic Neonatal Encephalopathy : Animal Experiments for Neuroprotective Therapies. Stroke Research and Treatment،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-488997
Modern Language Association (MLA)
Sameshima, Hiroshi& Ikenoue, Tsuyomu. Hypoxic-Ischemic Neonatal Encephalopathy : Animal Experiments for Neuroprotective Therapies. Stroke Research and Treatment No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-488997
American Medical Association (AMA)
Sameshima, Hiroshi& Ikenoue, Tsuyomu. Hypoxic-Ischemic Neonatal Encephalopathy : Animal Experiments for Neuroprotective Therapies. Stroke Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-488997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488997