Antidepressive-Like Property of Dichloromethane Fraction of Pimenta pseudocaryophyllus and Relevance of Monoamine Metabolic Enzymes
Joint Authors
Realino de Paula, José
Martins, José Luís Rodrigues
Ghedini, Paulo César
Fajemiroye, James Oluwagbamigbe
Galdino, Pablinny Morreira
Da Rocha, Fabio Fagundes
Costa, Elson Alves
Paula, Joelma Abadia Marciano de
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Pimenta pseudocaryophyllus popularly referred to as craveiro is considered as a calming agent in different local preparations.
The present study attempted to examine antidepressant-like effect of dichloromethane fraction (DF) and role of monoamine oxidase (MAO), tryptophan, and tyrosine hydroxylase.
Based on the research focus, tail suspension (TS), forced swimming (FS), and open field (OF) tests were conducted after oral administration of DF (125, 250, or 500 mg/Kg).
Ex vivo assay of MAO was also conducted to evaluate inhibitory effect of DF (250 mg/Kg).
Administration of DF elicits antidepressant-like response in the TS and FS.
However, DF 500 mg/Kg did not alter mice performance in these models.
The data obtained in the OF showed a reduction in total crossing and rearing activity; these effects suggest motor interference in TS and FS performance.
Mice pretreatment with p-chlorophenylalanine methyl ester (PCPA) (100 mg/kg, i.p.—serotonin biosynthesis inhibitor) for 4 consecutive days or acute administration of α-methyl-p-tyrosine (AMPT) (100 mg/kg, i.p.—catecholamine synthesis inhibitor) blocked anti-immobility effect of DF in the FS.
In ex vivo assay of MAO, DF did not inhibit catabolic activity of MAO.
Our findings support antidepressant-like activity of DF and suggest an effect that depends on monoamine biosynthesis.
American Psychological Association (APA)
Fajemiroye, James Oluwagbamigbe& Martins, José Luís Rodrigues& Ghedini, Paulo César& Galdino, Pablinny Morreira& Paula, Joelma Abadia Marciano de& Realino de Paula, José…[et al.]. 2013. Antidepressive-Like Property of Dichloromethane Fraction of Pimenta pseudocaryophyllus and Relevance of Monoamine Metabolic Enzymes. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-488998
Modern Language Association (MLA)
Fajemiroye, James Oluwagbamigbe…[et al.]. Antidepressive-Like Property of Dichloromethane Fraction of Pimenta pseudocaryophyllus and Relevance of Monoamine Metabolic Enzymes. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-488998
American Medical Association (AMA)
Fajemiroye, James Oluwagbamigbe& Martins, José Luís Rodrigues& Ghedini, Paulo César& Galdino, Pablinny Morreira& Paula, Joelma Abadia Marciano de& Realino de Paula, José…[et al.]. Antidepressive-Like Property of Dichloromethane Fraction of Pimenta pseudocaryophyllus and Relevance of Monoamine Metabolic Enzymes. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-488998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488998