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Therapeutic Effect of Chung-Pae, an Experimental Herbal Formula, on Acute Lung Inflammation Is Associated with Suppression of NF-κB and Activation of Nrf2
Joint Authors
Joo, Myungsoo
Kim, Do-Hyun
Jung, Hee Jae
Kim, Kwan-Il
Jeong, Nara
Choi, Jun-Yong
Kim, Kyun Ha
Jung, Sung-ki
Lee, Mei
Kim, Yong Ho
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Acute lung injury (ALI) is an inflammatory disease with high mortality, but therapeutics against it is unavailable.
Recently, we elaborated a formula, named Chung-pae (CP), that comprises four ethnic herbs commonly prescribed against various respiratory diseases in Asian traditional medicine.
CP is being administered in aerosol to relieve various respiratory symptoms of patients in our clinic.
Here, we sought to examine whether CP has a therapeutic effect on ALI and to uncover the mechanism behind it.
Reporter assays show that CP suppressed the transcriptional activity of proinflammatory NF-κB and activated that of anti-inflammatory Nrf2.
Similarly, CP suppressed the expression of NF-κB dependent, proinflammatory cytokines and induced that of Nrf2 dependent genes in RAW 264.7.
An aerosol intratracheal administration of CP effectively reduced neutrophilic infiltration and the expression of pro-inflammatory cytokines, hallmarks of ALI, in the lungs of mice that received a prior intraperitoneal injection of lipopolysaccharide.
The intratracheal CP administration concomitantly enhanced the expression of Nrf2 dependent genes in the lung.
Therefore, our results evidenced a therapeutic effect of CP on ALI, in which differential regulation of the two key inflammatory factors, NF-κB and Nrf2, was involved.
We propose that CP can be a new therapeutic formula against ALI.
American Psychological Association (APA)
Kim, Kyun Ha& Kim, Do-Hyun& Jeong, Nara& Kim, Kwan-Il& Kim, Yong Ho& Lee, Mei…[et al.]. 2013. Therapeutic Effect of Chung-Pae, an Experimental Herbal Formula, on Acute Lung Inflammation Is Associated with Suppression of NF-κB and Activation of Nrf2. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-489011
Modern Language Association (MLA)
Kim, Kyun Ha…[et al.]. Therapeutic Effect of Chung-Pae, an Experimental Herbal Formula, on Acute Lung Inflammation Is Associated with Suppression of NF-κB and Activation of Nrf2. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-489011
American Medical Association (AMA)
Kim, Kyun Ha& Kim, Do-Hyun& Jeong, Nara& Kim, Kwan-Il& Kim, Yong Ho& Lee, Mei…[et al.]. Therapeutic Effect of Chung-Pae, an Experimental Herbal Formula, on Acute Lung Inflammation Is Associated with Suppression of NF-κB and Activation of Nrf2. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-489011
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489011