Occipital Artery Function during the Development of 2-Kidney, 1-Clip Hypertension in Rats
Joint Authors
Robertson, Tom P.
Lewis, Stephen J.
Lewis, Tristan H.
Schmiedt, Chad W.
Chelko, Stephen P.
Source
International Journal of Vascular Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study compared the contractile responses elicited by angiotensin II (AII), arginine vasopressin (AVP), and 5-hydroxytryptamine (5-HT) in isolated occipital arteries (OAs) from sham-operated (SHAM) and 2-kidney, 1-clip (2K-1C) hypertensive rats.
OAs were isolated and bisected into proximal segments (closer to the common carotid artery) and distal segments (closer to the nodose ganglion) and mounted separately on myographs.
On day 9, 2K-1C rats had higher mean arterial blood pressures, heart rates, and plasma renin concentrations than SHAM rats.
The contractile responses to AII were markedly diminished in both proximal and distal segments of OAs from 2K-1C rats as compared to those from SHAM rats.
The responses elicited by AVP were substantially greater in distal than in proximal segments of OAs from SHAM rats and that AVP elicited similar responses in OA segments from 2K-1C rats.
The responses elicited by 5-HT were similar in proximal and distal segments from SHAM and 2K-1C rats.
These results demonstrate that continued exposure to circulating AII and AVP in 2K-1C rats reduces the contractile efficacy of AII but not AVP or 5-HT.
The diminished responsiveness to AII may alter the physiological status of OAs in vivo.
American Psychological Association (APA)
Chelko, Stephen P.& Schmiedt, Chad W.& Lewis, Tristan H.& Robertson, Tom P.& Lewis, Stephen J.. 2014. Occipital Artery Function during the Development of 2-Kidney, 1-Clip Hypertension in Rats. International Journal of Vascular Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-489033
Modern Language Association (MLA)
Chelko, Stephen P.…[et al.]. Occipital Artery Function during the Development of 2-Kidney, 1-Clip Hypertension in Rats. International Journal of Vascular Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-489033
American Medical Association (AMA)
Chelko, Stephen P.& Schmiedt, Chad W.& Lewis, Tristan H.& Robertson, Tom P.& Lewis, Stephen J.. Occipital Artery Function during the Development of 2-Kidney, 1-Clip Hypertension in Rats. International Journal of Vascular Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-489033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489033