![](/images/graphics-bg.png)
Phosphatases : The New Brakes for Cancer Development?
Joint Authors
Claret, Francois X.
Zhang, Qingxiu
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The phosphatidylinositol 3-kinase (PI3K) pathway plays a pivotal role in the maintenance of processes such as cell growth, proliferation, survival, and metabolism in all cells and tissues.
Dysregulation of the PI3K/Akt signaling pathway occurs in patients with many cancers and other disorders.
This aberrant activation of PI3K/Akt pathway is primarily caused by loss of function of all negative controllers known as inositol polyphosphate phosphatases and phosphoprotein phosphatases.
Recent studies provided evidence of distinct functions of the four main phosphatases—phosphatase and tensin homologue deleted on chromosome 10 (PTEN), Src homology 2-containing inositol 5′-phosphatase (SHIP), inositol polyphosphate 4-phosphatase type II (INPP4B), and protein phosphatase 2A (PP2A)—in different tissues with respect to regulation of cancer development.
We will review the structures and functions of PTEN, SHIP, INPP4B, and PP2A phosphatases in suppressing cancer progression and their deregulation in cancer and highlight recent advances in our understanding of the PI3K/Akt signaling axis.
American Psychological Association (APA)
Zhang, Qingxiu& Claret, Francois X.. 2011. Phosphatases : The New Brakes for Cancer Development?. Enzyme Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-489036
Modern Language Association (MLA)
Zhang, Qingxiu& Claret, Francois X.. Phosphatases : The New Brakes for Cancer Development?. Enzyme Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-489036
American Medical Association (AMA)
Zhang, Qingxiu& Claret, Francois X.. Phosphatases : The New Brakes for Cancer Development?. Enzyme Research. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-489036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489036