Do Somatic Mitochondrial DNA Mutations Contribute to Parkinson's Disease?
Joint Authors
Clark, Joanne
Simon, David K.
Dai, Ying
Source
Mathematical Problems in Engineering
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A great deal of evidence supports a role for mitochondrial dysfunction in the pathogenesis of Parkinson's disease (PD), although the origin of the mitochondrial dysfunction in PD remains unclear.
Expression of mitochondrial DNA (mtDNA) from PD patients in “cybrid” cell lines recapitulates the mitochondrial defect, implicating a role for mtDNA mutations, but the specific mutations responsible for the mitochondrial dysfunction in PD have been difficult to identify.
Somatic mtDNA point mutations and deletions accumulate with age and reach high levels in substantia nigra (SN) neurons.
Mutations in mitochondrial DNA polymerase γ (POLG) that lead to the accumulation of mtDNA mutations are associated with a premature aging phenotype in “mutator” mice, although overt parkinsonism has not been reported in these mice, and with parkinsonism in humans.
Together these data support, but do not yet prove, the hypothesis that the accumulation of somatic mtDNA mutations in SN neurons contribute to the pathogenesis of PD.
American Psychological Association (APA)
Clark, Joanne& Dai, Ying& Simon, David K.. 2011. Do Somatic Mitochondrial DNA Mutations Contribute to Parkinson's Disease?. Mathematical Problems in Engineering،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-489044
Modern Language Association (MLA)
Clark, Joanne…[et al.]. Do Somatic Mitochondrial DNA Mutations Contribute to Parkinson's Disease?. Mathematical Problems in Engineering No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-489044
American Medical Association (AMA)
Clark, Joanne& Dai, Ying& Simon, David K.. Do Somatic Mitochondrial DNA Mutations Contribute to Parkinson's Disease?. Mathematical Problems in Engineering. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-489044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489044