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Aggressive Palliation in Extensive Stage Small Cell Lung Cancer, Practice Guidelines versus Clinical Practice : A Case Report and Review of the Literature
Joint Authors
Jacimore, Laura L.
Nelson, John W.
Miles, Edward F.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Small cell lung cancer (SCLC) constitutes approximately 16% of all primary lung cancers, with more than 35,000 new cases per year.
Two-thirds of patients present with extensive stage disease (ES-SCLC) due to a tendency to metastasize early.
Outcomes remain poor, with a median survival of approximately 10 months and a two-year overall survival of <10%.
Current recommendations call for combination chemotherapy alone in patients without localized symptoms.
Thoracic radiation therapy following a good clinical response is controversial.
We report on a patient with ES-SCLC that had an excellent response to chemotherapy and underwent whole brain radiotherapy for a known brain metastasis and consolidative radiotherapy to the thorax.
His latest follow-up demonstrates only a stable residual pulmonary nodule and no evidence of active metastatic disease.
ES-SCLC is a relatively common presentation with a variable burden of metastatic disease.
In the absence of randomized trials demonstrating the efficacy of thoracic radiation therapy, the community radiation oncologist is placed in a difficult position when addressing these patients, particularly those with otherwise good performance status and a good response to initial systemic chemotherapy.
More research in this area is sorely needed to help guide treatment recommendations.
American Psychological Association (APA)
Miles, Edward F.& Jacimore, Laura L.& Nelson, John W.. 2011. Aggressive Palliation in Extensive Stage Small Cell Lung Cancer, Practice Guidelines versus Clinical Practice : A Case Report and Review of the Literature. Lung Cancer International،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-489064
Modern Language Association (MLA)
Miles, Edward F.…[et al.]. Aggressive Palliation in Extensive Stage Small Cell Lung Cancer, Practice Guidelines versus Clinical Practice : A Case Report and Review of the Literature. Lung Cancer International No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-489064
American Medical Association (AMA)
Miles, Edward F.& Jacimore, Laura L.& Nelson, John W.. Aggressive Palliation in Extensive Stage Small Cell Lung Cancer, Practice Guidelines versus Clinical Practice : A Case Report and Review of the Literature. Lung Cancer International. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-489064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489064