Recombinant Human Thyrotropin-Aided Radioiodine Therapy in Patients with Metastatic Differentiated Thyroid Carcinoma
Joint Authors
Besic, Nikola
Schwarzbartl-Pevec, Andreja A.
Zagar, Ivana
Vidergar-Kralj, Barbara
Horvat, Rika
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Our aim was to test the efficacy of 131-I therapy (RIT) using recombinant human TSH (rhTSH) in patients with differentiated thyroid carcinoma (DTC) in whom endogenous TSH stimulation was not an option due to the poor patient's physical condition or due to the disease progression during L-thyroxin withdrawal.
The study comprised 18 patients, who already have undergone total or near-total thyroidectomy and radioiodine ablation and 0–12 (median 5) RITs after L-thyroxin withdrawal.
Our patients received altogether 44 RITs using rhTSH while on L-thyroxin.
Six to 12 months after the first rhTSH-aided RIT, PR and SD was achieved in 3/18 (17%) and 4/18 patients (22%), respectively.
In most patients (n = 12; 61%) disease progressed despite rhTSH-aided RITs.
As a conclusion, rhTSH-aided RIT proved to add some therapeutic benefit in 39% our patients with metastatic DTC, who otherwise could not be efficiently treated with RIT.
American Psychological Association (APA)
Zagar, Ivana& Schwarzbartl-Pevec, Andreja A.& Vidergar-Kralj, Barbara& Horvat, Rika& Besic, Nikola. 2011. Recombinant Human Thyrotropin-Aided Radioiodine Therapy in Patients with Metastatic Differentiated Thyroid Carcinoma. Journal of Thyroid Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-489082
Modern Language Association (MLA)
Zagar, Ivana…[et al.]. Recombinant Human Thyrotropin-Aided Radioiodine Therapy in Patients with Metastatic Differentiated Thyroid Carcinoma. Journal of Thyroid Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-489082
American Medical Association (AMA)
Zagar, Ivana& Schwarzbartl-Pevec, Andreja A.& Vidergar-Kralj, Barbara& Horvat, Rika& Besic, Nikola. Recombinant Human Thyrotropin-Aided Radioiodine Therapy in Patients with Metastatic Differentiated Thyroid Carcinoma. Journal of Thyroid Research. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-489082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489082