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No Prognostic Impact of p53 and P-Glycoprotein Expression in Patients with Diffuse Large B-Cell Lymphoma
Joint Authors
Kayasut, Kanita
Lekhakula, Arnuparp
Sriplung, Hutcha
Rujirojindakul, Pairaya
Aiempanakit, Kumpol
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this study was to determine the clinical significances of p53 and p-glycoprotein (P-gp) expression on outcome predictors for patients with DLBC.
We assessed the immunohistochemical expression of p53 and P-gp using formalin-fixed, paraffin-embedded specimens in 108 patients diagnosed with de novo DLBC.
A high expression of p53 was found in 53.7% of the patients.
No expression of P-gp was demonstrated in any of the specimens.
There were no significant differences in the complete remission (CR) rate (P=0.79), overall survival (OS) (P=0.73), or disease-free survival (DFS) (P=31) between the p53-positive and p53-negative groups.
The final model from multivariate analysis that revealed poor performance status was significantly associated with CR (P<0.001) and OS (P<0.001).
Moreover, the advanced stage was a significant predictor of DFS (P=0.03).
This study demonstrated no impact of the expression of p53 on either response or survival rates.
American Psychological Association (APA)
Rujirojindakul, Pairaya& Aiempanakit, Kumpol& Kayasut, Kanita& Lekhakula, Arnuparp& Sriplung, Hutcha. 2011. No Prognostic Impact of p53 and P-Glycoprotein Expression in Patients with Diffuse Large B-Cell Lymphoma. ISRN Oncology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-489103
Modern Language Association (MLA)
Rujirojindakul, Pairaya…[et al.]. No Prognostic Impact of p53 and P-Glycoprotein Expression in Patients with Diffuse Large B-Cell Lymphoma. ISRN Oncology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-489103
American Medical Association (AMA)
Rujirojindakul, Pairaya& Aiempanakit, Kumpol& Kayasut, Kanita& Lekhakula, Arnuparp& Sriplung, Hutcha. No Prognostic Impact of p53 and P-Glycoprotein Expression in Patients with Diffuse Large B-Cell Lymphoma. ISRN Oncology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-489103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489103