Regulation of Serum Response Factor and Adiponectin by PPARγ Agonist Docosahexaenoic Acid
Joint Authors
Wei, Jeanne Y.
Ranganathan, Gouri
Williams, Roslyn
Johnson, Clayton
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Recent studies indicate that significant health benefits involving the regulation of signaling proteins result from the consumption of omega-3 polyunsaturated fatty acids (ω-3 PUFAs).
Serum response factor (SRF) is involved in transcriptional regulation of muscle growth and differentiation.
SRF levels are increased in the aging heart muscle.
It has not been examined whether SRF is made by adipocytes and whether SRF secretion by adipocytes is modulated by PPARγ agonist DHA.
Adiponectin is made exclusively by adipocytes.
We and others have previously reported that PUFAs such as DHA increase adiponectin levels and secretion in adipocytes.
Here we show that DHA downregulates SRF with a simultaneous upregulation of adiponectin and that both these responses are reversible by PPARγ antagonist.
Furthermore, there appears to be a direct relationship between DHA exposure and increased levels of membrane-associated high-density adiponectin, as well as lower levels of membrane-associated SRF.
Thus, we find that the levels of SRF and adiponectin are inversely related in response to treatment with PPARγ agonist DHA.
Decreased levels of SRF along with increase in membrane-associated adiponectin could in part mediate the health benefits of DHA.
American Psychological Association (APA)
Johnson, Clayton& Williams, Roslyn& Wei, Jeanne Y.& Ranganathan, Gouri. 2010. Regulation of Serum Response Factor and Adiponectin by PPARγ Agonist Docosahexaenoic Acid. Journal of Lipids،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-489115
Modern Language Association (MLA)
Johnson, Clayton…[et al.]. Regulation of Serum Response Factor and Adiponectin by PPARγ Agonist Docosahexaenoic Acid. Journal of Lipids No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-489115
American Medical Association (AMA)
Johnson, Clayton& Williams, Roslyn& Wei, Jeanne Y.& Ranganathan, Gouri. Regulation of Serum Response Factor and Adiponectin by PPARγ Agonist Docosahexaenoic Acid. Journal of Lipids. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-489115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489115