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Effect of Antimicrobial Peptide-Amide : Indolicidin on Biological Membranes
Joint Authors
Végh, Attila Gergely
Váró, György
Szegletes, Zsolt
Kerényi, Ádám
Nagy, Krisztina
Rákhely, Gábor
Bálint, Zoltán
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Indolicidin, a cationic antimicrobial tridecapeptide amide, is rich in proline and tryptophan residues.
Its biological activity is intensively studied, but the details how indolicidin interacts with membranes are not fully understood yet.
We report here an in situ atomic force microscopic study describing the effect of indolicidin on an artificial supported planar bilayer membrane of dipalmitoyl phosphatidylcholine (DPPC) and on purple membrane of Halobacterium salinarum.
Concentration dependent interaction of the peptide and membranes was found in case of DPPC resulting the destruction of the membrane.
Purple membrane was much more resistant against indolicidin, probably due to its high protein content.
Indolicidin preferred the border of membrane disks, where the lipids are more accessible.
These data suggest that the atomic force microscope is a powerful tool in the study of indolicidin-membrane interaction.
American Psychological Association (APA)
Végh, Attila Gergely& Nagy, Krisztina& Bálint, Zoltán& Kerényi, Ádám& Rákhely, Gábor& Váró, György…[et al.]. 2011. Effect of Antimicrobial Peptide-Amide : Indolicidin on Biological Membranes. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-489132
Modern Language Association (MLA)
Végh, Attila Gergely…[et al.]. Effect of Antimicrobial Peptide-Amide : Indolicidin on Biological Membranes. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-489132
American Medical Association (AMA)
Végh, Attila Gergely& Nagy, Krisztina& Bálint, Zoltán& Kerényi, Ádám& Rákhely, Gábor& Váró, György…[et al.]. Effect of Antimicrobial Peptide-Amide : Indolicidin on Biological Membranes. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-489132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489132