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Bromodomain-Containing Protein 4 : A Dynamic Regulator of Breast Cancer Metastasis through Modulation of the Extracellular Matrix
Joint Authors
Source
International Journal of Breast Cancer
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Metastasis is an extremely complex process that accounts for most cancer-related deaths.
Malignant primary tumors can be removed surgically, but the cells that migrate, invade, and proliferate at distant organs are often the cells that prove most difficult to target therapeutically.
There is growing evidence that host factors outside of the primary tumors are of major importance in the development of metastasis.
Recently, we have shown that the bromodomain-containing protein 4 or bromodomain 4 (Brd4) functions as an inherited susceptibility gene for breast cancer progression and metastasis.
In this paper, we will discuss that host genetic background on which a tumor arises can significantly alter the biology of the subsequent metastatic disease, and we will focus on the role of Brd4 in regulating metastasis susceptibility.
American Psychological Association (APA)
Alsarraj, Jude& Hunter, Kent W.. 2011. Bromodomain-Containing Protein 4 : A Dynamic Regulator of Breast Cancer Metastasis through Modulation of the Extracellular Matrix. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-489138
Modern Language Association (MLA)
Alsarraj, Jude& Hunter, Kent W.. Bromodomain-Containing Protein 4 : A Dynamic Regulator of Breast Cancer Metastasis through Modulation of the Extracellular Matrix. International Journal of Breast Cancer No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-489138
American Medical Association (AMA)
Alsarraj, Jude& Hunter, Kent W.. Bromodomain-Containing Protein 4 : A Dynamic Regulator of Breast Cancer Metastasis through Modulation of the Extracellular Matrix. International Journal of Breast Cancer. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-489138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489138