Plastic Changes in the Spinal Cord in Motor Neuron Disease
Joint Authors
Biagioni, Francesca
Fornai, Francesco
Ferrucci, Michela
Lenzi, Paola
Flaibani, Marina
Siciliano, Gabriele
Falleni, Alessandra
Giannessi, Francesco
Paparelli, Antonio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
In the present paper, we analyze the cell number within lamina X at the end stage of disease in a G93A mouse model of ALS; the effects induced by lithium; the stem-cell like phenotype of lamina X cells during ALS; the differentiation of these cells towards either a glial or neuronal phenotype.
In summary we found that G93A mouse model of ALS produces an increase in lamina X cells which is further augmented by lithium administration.
In the absence of lithium these nestin positive stem-like cells preferentially differentiate into glia (GFAP positive), while in the presence of lithium these cells differentiate towards a neuron-like phenotype (βIII-tubulin, NeuN, and calbindin-D28K positive).
These effects of lithium are observed concomitantly with attenuation in disease progression and are reminiscent of neurogenetic effects induced by lithium in the subependymal ventricular zone of the hippocampus.
American Psychological Association (APA)
Fornai, Francesco& Ferrucci, Michela& Lenzi, Paola& Falleni, Alessandra& Biagioni, Francesca& Flaibani, Marina…[et al.]. 2014. Plastic Changes in the Spinal Cord in Motor Neuron Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-489146
Modern Language Association (MLA)
Fornai, Francesco…[et al.]. Plastic Changes in the Spinal Cord in Motor Neuron Disease. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-489146
American Medical Association (AMA)
Fornai, Francesco& Ferrucci, Michela& Lenzi, Paola& Falleni, Alessandra& Biagioni, Francesca& Flaibani, Marina…[et al.]. Plastic Changes in the Spinal Cord in Motor Neuron Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-489146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489146