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Effect of Caloric Restriction on Hepatic Sinusoidal System and Stellate Cells in Mice
Joint Authors
King, Kara
Chen, Jian
Zhang, Jian X.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Aging associated changes in liver include reduced hepatic blood flow, increased number of stellate cells, and collagen deposits in perisinusoidal space.
We tested the possibility of mitigating these changes with caloric restriction.
Two-month-old mice were subjected to 30 percent caloric restriction for 12 months and then examined for the effect of caloric restriction on the sinusoidal network, collagen deposition, and the number of stellate cells.
Using intravital fluorescence microscopy, assessments were made on sinusoidal diameter, density, volumetric flow, perfusion index, and autofluorescence of vitamin A that was primarily stored with lipid droplets in stellate cells.
A significant effect was observed in the vitamin A autofluorescence of stellate cells; stellate cell associated fluorescence was diminished in terms of number and size of fluorescent spots.
Caloric restriction reduced collagen deposits in liver sections and lowered the gene expression of α1-(I) collagen but not α-smooth muscle actin.
No differences were detected in sinusoidal dimension measurements.
Our results showed that caloric restriction was effective in ameliorating the increase in stellate cells and the mild fibrosis in old mice.
However, caloric restriction had no impact on stellate cell activity level as indicated by the unaffected α-smooth muscle actin expression.
American Psychological Association (APA)
Chen, Jian& King, Kara& Zhang, Jian X.. 2014. Effect of Caloric Restriction on Hepatic Sinusoidal System and Stellate Cells in Mice. Journal of Aging Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-489154
Modern Language Association (MLA)
Chen, Jian…[et al.]. Effect of Caloric Restriction on Hepatic Sinusoidal System and Stellate Cells in Mice. Journal of Aging Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-489154
American Medical Association (AMA)
Chen, Jian& King, Kara& Zhang, Jian X.. Effect of Caloric Restriction on Hepatic Sinusoidal System and Stellate Cells in Mice. Journal of Aging Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-489154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489154