Genome-Wide miRNA Seeds Prediction in Archaea
Joint Authors
Wang, Shengqin
Xu, Yuming
Lu, Zuhong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Growing evidence indicates that miRNA genes exist in the archaeal genome, though the functional role of such noncoding RNA remains unclear.
Here, we integrated the phylogenetic information of available archaeal genomes to predict miRNA seeds (typically defined as the 2–8 nucleotides of mature miRNAs) on the genomic scale.
Finally, we found 2649 candidate seeds with significant conservation signal.
Eleven of 29 unique seeds from previous study support our result (P value <0.01), which demonstrates that the pipeline is suitable to predict experimentally detectable miRNA seeds.
The statistical significance of the overlap between the detected archaeal seeds and known eukaryotic seeds shows that the miRNA may evolve before the divergence of these two domains of cellular life.
In addition, miRNA targets are enriched for genes involved in transcriptional regulation, which is consistent with the situation in eukaryote.
Our research will enhance the regulatory network analysis in Archaea.
American Psychological Association (APA)
Wang, Shengqin& Xu, Yuming& Lu, Zuhong. 2014. Genome-Wide miRNA Seeds Prediction in Archaea. Archaea،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-489167
Modern Language Association (MLA)
Wang, Shengqin…[et al.]. Genome-Wide miRNA Seeds Prediction in Archaea. Archaea No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-489167
American Medical Association (AMA)
Wang, Shengqin& Xu, Yuming& Lu, Zuhong. Genome-Wide miRNA Seeds Prediction in Archaea. Archaea. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-489167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489167