Polysaccharides-Rich Extract of Ganoderma lucidum (M.A. Curtis : Fr.) P. Karst Accelerates Wound Healing in Streptozotocin-Induced Diabetic Rats
Joint Authors
Abdullah, Noorlidah
Cheng, Poh-Guat
Abdulla, Mahmood Ameen
Phan, Chia-Wei
Kuppusamy, Umah Rani
Sabaratnam, Vikineswary
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ganoderma lucidum (M.A.
Curtis:Fr.) P.
Karst is a popular medicinal mushroom.
Scientific reports had shown that the wound healing effects of G.
lucidum were partly attributed to its rich polysaccharides.
However, little attention has been paid to its potential effects on wounds associated with diabetes mellitus.
In this study, we evaluated the wound healing activity of the hot aqueous extract of G.
lucidum in streptozotocin-induced diabetic rats.
The extract of G.
lucidum was standardised based on chemical contents (w/w) of total polysaccharides (25.1%), ganoderic acid A (0.45%), and adenosine (0.069%).
Six groups of six rats were experimentally wounded in the posterior neck region.
Intrasite gel was used as a positive control and aqueous cream as the placebo.
Topical application with 10% (w/w) of mushroom extract-incorporated aqueous cream was more effective than that with Intrasite gel in terms of wound closure.
The antioxidant activity in serum of rats treated with aqueous extract of G.
lucidum was significantly higher; whereas the oxidative protein products and lipid damage were lower when compared to those of the controls.
These findings strongly support the beneficial effects of standardised aqueous extract of G.
lucidum in accelerating wound healing in streptozotocin-induced diabetic rats.
American Psychological Association (APA)
Cheng, Poh-Guat& Phan, Chia-Wei& Sabaratnam, Vikineswary& Abdullah, Noorlidah& Abdulla, Mahmood Ameen& Kuppusamy, Umah Rani. 2013. Polysaccharides-Rich Extract of Ganoderma lucidum (M.A. Curtis : Fr.) P. Karst Accelerates Wound Healing in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489175
Modern Language Association (MLA)
Cheng, Poh-Guat…[et al.]. Polysaccharides-Rich Extract of Ganoderma lucidum (M.A. Curtis : Fr.) P. Karst Accelerates Wound Healing in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-489175
American Medical Association (AMA)
Cheng, Poh-Guat& Phan, Chia-Wei& Sabaratnam, Vikineswary& Abdullah, Noorlidah& Abdulla, Mahmood Ameen& Kuppusamy, Umah Rani. Polysaccharides-Rich Extract of Ganoderma lucidum (M.A. Curtis : Fr.) P. Karst Accelerates Wound Healing in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489175