![](/images/graphics-bg.png)
Microbial Sensing by the Intestinal Epithelium in the Pathogenesis of Inflammatory Bowel Disease
Joint Authors
Scharl, Michael
Gerhard Rogler, G.
Source
International Journal of Inflammation
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Recent years have raised evidence that the intestinal microbiota plays a crucial role in the pathogenesis of chronic inflammatory bowels diseases.
This evidence comes from several observations.
First, animals raised under germ-free conditions do not develop intestinal inflammation in several different model systems.
Second, antibiotics are able to modulate the course of experimental colitis.
Third, genetic polymorphisms in a variety of genes of the innate immune system have been associated with chronic intestinal inflammatory diseases.
Dysfunction of these molecules results in an inappropriate response to bacterial and antigenic stimulation of the innate immune system in the gastrointestinal tract.
Variants of pattern recognition receptors such as NOD2 or TLRs by which commensal and pathogenic bacteria can be detected have been shown to be involved in the pathogenesis of IBD.
But not only pathways of microbial detection but also intracellular ways of bacterial processing such as autophagosome function are associated with the risk to develop Crohn's disease.
Thus, the “environment concept” and the “genetic concept” of inflammatory bowel disease pathophysiology are converging via the intestinal microbiota and the recognition mechanisms for an invasion of members of the microbiota into the mucosa.
American Psychological Association (APA)
Scharl, Michael& Gerhard Rogler, G.. 2010. Microbial Sensing by the Intestinal Epithelium in the Pathogenesis of Inflammatory Bowel Disease. International Journal of Inflammation،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-489176
Modern Language Association (MLA)
Scharl, Michael& Gerhard Rogler, G.. Microbial Sensing by the Intestinal Epithelium in the Pathogenesis of Inflammatory Bowel Disease. International Journal of Inflammation No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-489176
American Medical Association (AMA)
Scharl, Michael& Gerhard Rogler, G.. Microbial Sensing by the Intestinal Epithelium in the Pathogenesis of Inflammatory Bowel Disease. International Journal of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-489176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489176