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Ixeris dentata NAKAI Reduces Clinical Score and HIF-1 Expression in Experimental Colitis in Mice
Joint Authors
Jeon, Yong-Deok
Jung, Hyun-Ju
Kim, Hyun-Ju
Kim, Dae-Seung
Poudel, Amrit
Choi, Byung-Min
Park, Sang-Hyun
Park, Jin-Han
Hong, Seung-Heon
Ku, Sae-Kwang
Kim, Su-Jin
Ko, Jang-Ho
Um, Jae-Young
Park, Sung-Joo
Han, Yo-Han
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ixeris dentata (ID) is an herbal medicine used in Asian countries to treat indigestion, pneumonia, hepatitis, contusions, and tumors; however, its effect on intestinal inflammation is unknown.
Thus, we investigated the effect of ID in the dextran sulfate sodium (DSS) model of colitis in female BALB/c mice; animals were evaluated after seven days of DSS treatment.
DSS-treated mice showed considerable clinical signs, including weight loss, reduced colon length, colonic epithelial injury, infiltration of inflammatory cells in the colon tissue, and upregulation of inflammatory mediators.
However, administration of ID attenuated body weight loss, colon shortening, and the increase in disease activity index score.
ID also significantly decreased the colonic mucosal injury and the number of infiltrating mast cells.
Moreover, ID inhibited the expressions of cyclooxygenase-2 and hypoxia-inducible factor-1α in colon tissue.
Taken together, the results provide experimental evidence that ID might be a useful therapy for patients with ulcerative colitis.
American Psychological Association (APA)
Kim, Dae-Seung& Ko, Jang-Ho& Jeon, Yong-Deok& Han, Yo-Han& Kim, Hyun-Ju& Poudel, Amrit…[et al.]. 2013. Ixeris dentata NAKAI Reduces Clinical Score and HIF-1 Expression in Experimental Colitis in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489179
Modern Language Association (MLA)
Kim, Dae-Seung…[et al.]. Ixeris dentata NAKAI Reduces Clinical Score and HIF-1 Expression in Experimental Colitis in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-489179
American Medical Association (AMA)
Kim, Dae-Seung& Ko, Jang-Ho& Jeon, Yong-Deok& Han, Yo-Han& Kim, Hyun-Ju& Poudel, Amrit…[et al.]. Ixeris dentata NAKAI Reduces Clinical Score and HIF-1 Expression in Experimental Colitis in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489179