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Molecular Targeted Approaches for Advanced BRAF V600, N-RAS, c-KIT, and GNAQ Melanomas
Joint Authors
Pietro, Loschi
Giovanni, Ponti
Longo, Caterina
Tomasi, Aldo
Luppi, Gabriele
Gelsomino, Fabio
Pellacani, Giovanni
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
The introduction of a newly developed target therapy for metastatic melanomas poses the challenge to have a good molecular stratification of those patients who may benefit from this therapeutic option.
Practically, BRAF mutation status (V600E) is commonly screened although other non-V600E mutations (i.e., K-R-M-D) could be found in some patients who respond to therapy equally to the patients harboring V600E mutations.
Furthermore, other mutations, namely, N-RAS, KIT, and GNAQ, should be sequenced according to distinct melanoma specific subtypes and clinical aspects.
In our report, a practical flow chart is described along with our experience in this field.Erratum to “Molecular Targeted Approaches for Advanced BRAF V600, N-RAS, c-KIT, and GNAQ Melanoma”dx.doi.org/10.1155/2014/246751
American Psychological Association (APA)
Giovanni, Ponti& Pellacani, Giovanni& Tomasi, Aldo& Pietro, Loschi& Luppi, Gabriele& Gelsomino, Fabio…[et al.]. 2014. Molecular Targeted Approaches for Advanced BRAF V600, N-RAS, c-KIT, and GNAQ Melanomas. Disease Markers،Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-489180
Modern Language Association (MLA)
Giovanni, Ponti…[et al.]. Molecular Targeted Approaches for Advanced BRAF V600, N-RAS, c-KIT, and GNAQ Melanomas. Disease Markers No. 2014 (2014), pp.1-3.
https://search.emarefa.net/detail/BIM-489180
American Medical Association (AMA)
Giovanni, Ponti& Pellacani, Giovanni& Tomasi, Aldo& Pietro, Loschi& Luppi, Gabriele& Gelsomino, Fabio…[et al.]. Molecular Targeted Approaches for Advanced BRAF V600, N-RAS, c-KIT, and GNAQ Melanomas. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-489180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489180