Antidiabetic Effect of Sida cordata in Alloxan Induced Diabetic Rats
Joint Authors
Shah, Naseer Ali
Khan, Muhammad Rashid
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Medicinal plants are efficient ameliorator of oxidative stress associated with diabetes mellitus.
In this study, ethyl acetate fraction (SCEE) of Sida cordata was investigated for scientific validation of its folk use in diabetes.
Antidiabetic effect of SCEE was confirmed by antihyperglycemic activity in normal glucose loaded and diabetic glucose loaded animals as well as normal off feed animals.
Confirmation of antidiabetic activity and toxicity ameliorative role of S.
cordata was investigated in a chronic multiple dose treatment study of fifteen days.
A single dose of alloxan (120 mg/kg) produced a decrease in insulin level, hyperglycemia, elevated total lipids, triglycerides, and cholesterol and decreased the high-density lipoproteins.
Concurrent with these changes, there was an increase in the concentration of lipid peroxidation (TBARS), H2O2, and nitrite in pancreas, liver, and testis.
This oxidative stress was related to a decrease in glutathione content (GSH) and antioxidant enzymes.
Administration of SCEE for 15 days after diabetes induction ameliorated hyperglycemia, restored lipid profile, blunted the increase in TBARS, H2O2, and nitrite content, and stimulated the GSH production in the organs of alloxan-treated rats.
We suggested that SCEE could be used as antidiabetic component in case of diabetes mellitus.
This may be related to its antioxidative properties.
American Psychological Association (APA)
Shah, Naseer Ali& Khan, Muhammad Rashid. 2014. Antidiabetic Effect of Sida cordata in Alloxan Induced Diabetic Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-489183
Modern Language Association (MLA)
Shah, Naseer Ali& Khan, Muhammad Rashid. Antidiabetic Effect of Sida cordata in Alloxan Induced Diabetic Rats. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-489183
American Medical Association (AMA)
Shah, Naseer Ali& Khan, Muhammad Rashid. Antidiabetic Effect of Sida cordata in Alloxan Induced Diabetic Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-489183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489183