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Feleucins : Novel Bombinin Precursor-Encoded Nonapeptide Amides from the Skin Secretion of Bombina variegata
Joint Authors
Zhou, Mei
Wang, Lei
Hou, Xiaojuan
Bai, Bing
Ge, Lilin
Luo, Yu
Shaw, Chris
Chen, Tianbao
Ma, Chengbang
Duan, Jinao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The first amphibian skin antimicrobial peptide (AMP) to be identified was named bombinin, reflecting its origin from the skin of the European yellow-bellied toad (Bombina variegata).
Bombinins and their related peptides, the bombinin Hs, were subsequently reported from other bombinid toads.
Molecular cloning of bombinin-encoding cDNAs from skin found that bombinins and bombinin Hs were coencoded on the same precursor proteins.
Here, we report the molecular cloning of two novel cDNAs from a skin secretion-derived cDNA library of B.
variegata whose open-reading frames each encode a novel bombinin (GIGGALLNVGKVALKGLAKGLAEHFANamide) and a C-terminally located single copy of a novel nonapeptide (FLGLLGGLLamide or FLGLIGSLLamide).
These novel nonapeptides were named feleucin-BV1 and feleucin-BV2, respectively.
The novel bombinin exhibited 89% identity to homologues from the toads, B.
microdeladigitora and B.
maxima.
The feleucins exhibited no identity with any amphibian AMP archived in databases.
Synthetic feleucins exhibited a weak activity against Staphylococcus aureus (128–256 mg/L) but feleucin-BV1 exhibited a synergistic action with the novel bombinin.
The present report clearly demonstrates that the skin secretions of bombinid toads continue to represent a source of peptides of novel structure that could provide templates for the design of therapeutics.
American Psychological Association (APA)
Bai, Bing& Hou, Xiaojuan& Wang, Lei& Ge, Lilin& Luo, Yu& Ma, Chengbang…[et al.]. 2014. Feleucins : Novel Bombinin Precursor-Encoded Nonapeptide Amides from the Skin Secretion of Bombina variegata. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-489192
Modern Language Association (MLA)
Bai, Bing…[et al.]. Feleucins : Novel Bombinin Precursor-Encoded Nonapeptide Amides from the Skin Secretion of Bombina variegata. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-489192
American Medical Association (AMA)
Bai, Bing& Hou, Xiaojuan& Wang, Lei& Ge, Lilin& Luo, Yu& Ma, Chengbang…[et al.]. Feleucins : Novel Bombinin Precursor-Encoded Nonapeptide Amides from the Skin Secretion of Bombina variegata. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-489192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489192