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Drug Release Kinetics and Front Movement in Matrix Tablets Containing Diltiazem or Metoprololλ-Carrageenan Complexes
Joint Authors
Bonferoni, Maria Cristina
Bettini, Ruggero
Zanelotti, Laura
Caramella, Carla
Colombo, Paolo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In this work we investigated the moving boundaries and the associated drug release kinetics in matrix tablets prepared with two complexes between λ-carrageenan and two soluble model drugs, namely, diltiazem HCl and metoprolol tartrate aiming at clarifying the role played by drug/polymer interaction on the water uptake, swelling, drug dissolution, and drug release performance of the matrix.
The two studied complexes released the drug with different mechanism indicating two different drug/polymer interaction strengths.
The comparison between the drug release behaviour of the complexes and the relevant physical mixtures indicates that diltiazem gave rise to a less soluble and more stable complex with carrageenan than metoprolol.
The less stable metoprolol complex afforded an erodible matrix, whereas the stronger interaction between diltiazem and carrageenan resulted in a poorly soluble, slowly dissolving matrix.
It was concluded that the different stability of the studied complexes affords two distinct drug delivery systems: in the case of MTP, the dissociation of the complex, as a consequence of the interaction with water, affords a classical soluble matrix type delivery system; in the case of DTZ, the dissolving/diffusing species is the complex itself because of the very strong interaction between the drug and the polymer.
American Psychological Association (APA)
Bettini, Ruggero& Bonferoni, Maria Cristina& Colombo, Paolo& Zanelotti, Laura& Caramella, Carla. 2014. Drug Release Kinetics and Front Movement in Matrix Tablets Containing Diltiazem or Metoprololλ-Carrageenan Complexes. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-489205
Modern Language Association (MLA)
Bettini, Ruggero…[et al.]. Drug Release Kinetics and Front Movement in Matrix Tablets Containing Diltiazem or Metoprololλ-Carrageenan Complexes. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-489205
American Medical Association (AMA)
Bettini, Ruggero& Bonferoni, Maria Cristina& Colombo, Paolo& Zanelotti, Laura& Caramella, Carla. Drug Release Kinetics and Front Movement in Matrix Tablets Containing Diltiazem or Metoprololλ-Carrageenan Complexes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-489205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489205