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Metformin-Associated Lactic Acidosis following Intentional Overdose Successfully Treated with Tris-Hydroxymethyl Aminomethane and Renal Replacement Therapy
Joint Authors
House, Andrew A.
Sekhon, Gurbir
Lam, Ngan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A 43-year-old woman was brought to the hospital with severe metabolic acidosis (pH 6.56, bicarbonate 3 mmol/L, and lactate 18.4 mmol/L) and a serum creatinine of 162 μmol/L with a serum potassium of 7.8 mmol/L.
A delayed diagnosis of metformin-associated lactic acidosis was made, and she was treated with tris-hydroxymethyl aminomethane (THAM) and renal replacement therapy (RRT).
Following a complete recovery, she admitted to ingesting 180 tablets (90 grams) of metformin.
Her peak serum metformin concentration was 170 μg/mL (therapeutic range 1-2 μg/mL).
Our case demonstrates an intentional metformin overdose resulting in lactic acidosis in a nondiabetic patient who was successfully treated with THAM and RRT.
American Psychological Association (APA)
Lam, Ngan& Sekhon, Gurbir& House, Andrew A.. 2012. Metformin-Associated Lactic Acidosis following Intentional Overdose Successfully Treated with Tris-Hydroxymethyl Aminomethane and Renal Replacement Therapy. Case Reports in Nephrology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-489214
Modern Language Association (MLA)
Lam, Ngan…[et al.]. Metformin-Associated Lactic Acidosis following Intentional Overdose Successfully Treated with Tris-Hydroxymethyl Aminomethane and Renal Replacement Therapy. Case Reports in Nephrology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-489214
American Medical Association (AMA)
Lam, Ngan& Sekhon, Gurbir& House, Andrew A.. Metformin-Associated Lactic Acidosis following Intentional Overdose Successfully Treated with Tris-Hydroxymethyl Aminomethane and Renal Replacement Therapy. Case Reports in Nephrology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-489214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489214